You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SLC13A2
Solute carrier family 13 member 2

Protein Summary
Description
Cotransport of sodium ions and dicarboxylates such as succinate and citrate. The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of cyclophilin b. The encoded protein may play a role in the formation of kidney stones. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314669
  • ENSP00000316202
  • ENSG00000007216
  • ENST00000444914
  • ENSP00000392411

Symbol
  • NADC1
  • SDCT1
  • NaCT
  • NADC1
  • SDCT1
  • NaDC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
cell type or tissue
0.88
molecular function
0.84
gene perturbation
0.6
chemical
0.47


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.1   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.1   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
2
2
57.2
low density lipoprotein cholesterol measurement
1
2
2
48.3
sporadic amyotrophic lateral sclerosis
1
1
1
40.7
metabolite measurement
1
1
1
36.9
total cholesterol measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
2
57.2
low density lipoprotein cholesterol measurement
2
48.3
sporadic amyotrophic lateral sclerosis
1
40.7
metabolite measurement
1
36.9
total cholesterol measurement
1
29
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1276558
20500
Rat
RGD:61920
65202
Dog
solute carrier family 13 member 2
VGNC:46228
491167
Horse
solute carrier family 13 member 2
VGNC:23027
100072053
Cow
solute carrier family 13 member 2
VGNC:34674
505069
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
solute carrier family 13 member 2
Horse
solute carrier family 13 member 2
Cow
solute carrier family 13 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13183-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Protein-Protein Interactions (53)
1 – 10 of 53
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.999999926
p_ni:  2.2e-8
p_wrong:  5.2e-8
Score:  0.171
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.997947333
p_ni:  0.002052667
Score:  0.206
Data Source:  BioPlex,STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
p_int:  0.987202172
p_ni:  0.012352984
p_wrong:  0.000444843
Score:  0.232
Data Source:  BioPlex,STRINGDB
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.984708414
p_ni:  0.015291585
Score:  0.185
Data Source:  BioPlex,STRINGDB
SARAF
Tbio
Novelty:  0.0383833
p_int:  0.951702006
p_ni:  0.048160833
p_wrong:  0.000137161
Score:  0.173
Data Source:  BioPlex,STRINGDB
ELOA
Tbio
Novelty:  0.04334224
p_int:  0.906736516
p_ni:  0.003073605
p_wrong:  0.090189879
Score:  0.345
Data Source:  BioPlex,STRINGDB
TWISTNB
Tdark
Family:  Enzyme
Novelty:  0.59160737
p_int:  0.863301043
p_ni:  0.136698897
p_wrong:  6e-8
Score:  0.205
Data Source:  BioPlex,STRINGDB
SCAF4
Tbio
Novelty:  0.08174395
p_int:  0.823768614
p_ni:  0.002395622
p_wrong:  0.173835764
Score:  0.232
Data Source:  BioPlex,STRINGDB
AMFR
Tbio
Family:  Enzyme
Novelty:  0.00533547
p_int:  0.805641851
p_ni:  0.194358149
Score:  0.552
Data Source:  BioPlex,STRINGDB
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.799372621
p_ni:  0.200608792
p_wrong:  0.000018587
Score:  0.186
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  106.10

PubMed score by year
PubTator Score  46.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: