Tbio SLC13A2 Solute carrier family 13 member 2

Protein Summary

Description

Cotransport of sodium ions and dicarboxylates such as succinate and citrate. The protein encoded by this gene is a sodium-coupled citrate transporter that is regulated by the chaperone activity of cyclophilin b. The encoded protein may play a role in the formation of kidney stones. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• Q13183
• B2RBI9
• B4DPL1
• E7ETH5
• Q4VAR7

Gene Name

• SLC13A2

Ensembl ID

• ENST00000314669
• ENSP00000316202
• ENSG00000007216
• ENST00000444914
• ENSP00000392411

Symbol

• NADC1
• SDCT1
• NaCT
• NADC1
• SDCT1
• NaDC-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.91
cell type or tissue	0.88
molecular function	0.84
gene perturbation	0.6
chemical	0.47

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Solute Carrier Family 13 Member 2

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc13 Family Of Sodium-dependent Sulphate/carboxylate Transporters / Solute Carrier Family 13 Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.03   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.03   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0