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Tchem
PAK2
Serine/threonine-protein kinase PAK 2

Protein Summary
Description
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the ot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327134
  • ENSP00000314067
  • ENSG00000180370

Symbol
  • PAK65
  • PAKgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
hub protein
0.99
biological process
0.98
transcription factor perturbation
0.98
disease perturbation
0.96


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.83   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 791   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.83   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 791   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
90.5
monocyte count
3
2
3
89.1
myeloid white cell count
1
1
1
83.9
neutrophil count
2
1
2
78.2
leukocyte count
2
2
2
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
90.5
monocyte count
3
89.1
myeloid white cell count
1
83.9
neutrophil count
2
78.2
leukocyte count
2
72.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 2
VGNC:14627
460965
Macaque
p21 (RAC1) activated kinase 2
710314
Mouse
MGI:1339984
224105
Rat
RGD:61953
29432
Dog
p21 (RAC1) activated kinase 2
VGNC:53081
612814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 2
Macaque
p21 (RAC1) activated kinase 2
Mouse
Rat
Dog
p21 (RAC1) activated kinase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13177-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (140)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Adaptive Immune System
Reactome
Apoptosis
Reactome
Apoptotic execution phase
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Adaptive Immune System
Apoptosis
Apoptotic execution phase
Axon guidance
Gene Ontology Terms (41)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (272)
1 – 10 of 272
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.999999862
p_ni: 1.38e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999998147
p_ni: 0.000001802
p_wrong: 5.1e-8
Score: 0.939
Data Source: BioPlex,Reactome,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.999991513
p_ni: 0.000008487
Data Source: BioPlex
ARHGEF6
Tbio
Novelty: 0.02162737
p_int: 0.999989947
p_ni: 0.000009989
p_wrong: 6.4e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999974247
p_ni: 0.000025753
Data Source: BioPlex
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999229213
p_ni: 0.000770786
p_wrong: 1e-9
Score: 0.965
Data Source: BioPlex,Reactome,STRINGDB
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.998492111
p_ni: 0.001507889
Score: 0.174
Data Source: BioPlex,STRINGDB
FBXO28
Tbio
Novelty: 0.10548865
p_int: 0.995252231
p_ni: 0.004730771
p_wrong: 0.000016999
Data Source: BioPlex
OCRL
Tbio
Family: Enzyme
Novelty: 0.00555539
p_int: 0.993284146
p_ni: 0.005605052
p_wrong: 0.001110803
Score: 0.427
Data Source: BioPlex,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.985039533
p_ni: 0.014960467
Data Source: BioPlex
Publication Statistics
PubMed Score  80.83

PubMed score by year
PubTator Score  134.85

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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