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Tchem
MAPK7
Mitogen-activated protein kinase 7

Protein Summary
Description
Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299612
  • ENSP00000299612
  • ENSG00000166484
  • ENST00000308406
  • ENSP00000311005
  • ENST00000395602
  • ENSP00000378966
  • ENST00000395604
  • ENSP00000378968

Symbol
  • BMK1
  • ERK5
  • PRKM7
  • BMK1
  • ERK4
  • ERK5
  • PRKM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical bioactivity profile
1
molecular function
0.99
biological term
0.89
small molecule
0.89


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.52   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 563   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.52   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 563   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 7
VGNC:12424
454499
Macaque
mitogen-activated protein kinase 7
702837
Mouse
MGI:1346347
23939
Rat
RGD:6486357
100912585
Dog
mitogen-activated protein kinase 7
VGNC:43000
489532
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 7
Macaque
mitogen-activated protein kinase 7
Mouse
Rat
Dog
mitogen-activated protein kinase 7
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13164-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (78)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 42
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Axon guidance
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Protein-Protein Interactions (188)
1 – 10 of 188
MAP2K5
Tchem
Family: Kinase
Novelty: 0.00587774
p_int: 1
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.987
Data Source: Reactome,STRINGDB
MEF2A
Tbio
Family: TF
Novelty: 0.00439393
Score: 0.978
Data Source: Reactome,STRINGDB
MEF2D
Tbio
Family: TF
Novelty: 0.00732653
Score: 0.977
Data Source: STRINGDB
DUSP6
Tbio
Family: Enzyme
Novelty: 0.00426304
Score: 0.966
Data Source: Reactome,STRINGDB
DUSP7
Tbio
Family: Enzyme
Novelty: 0.05499898
Score: 0.961
Data Source: Reactome,STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.958
Data Source: STRINGDB
RPS6KA1
Tchem
Family: Kinase
Novelty: 0.00178073
Score: 0.956
Data Source: Reactome,STRINGDB
RPS6KA2
Tchem
Family: Kinase
Novelty: 0.00409407
Score: 0.95
Data Source: Reactome,STRINGDB
RPS6KA3
Tchem
Family: Kinase
Novelty: 0.00221219
Score: 0.948
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  446.52

PubMed score by year
PubTator Score  253.57

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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