Tchem MAPK7 Mitogen-activated protein kinase 7

Protein Summary

Description

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13164
• Q16634
• Q59F50
• Q6QLU7
• Q7L4P4
• Q969G1
• Q96G51
• MAP kinase 7

Gene Name

• MAPK7

Ensembl ID

• ENST00000299612
• ENSP00000299612
• ENSG00000166484
• ENST00000308406
• ENSP00000311005
• ENST00000395602
• ENSP00000378966
• ENST00000395604
• ENSP00000378968

Symbol

• BMK1
• ERK5
• PRKM7
• BMK1
• ERK4
• ERK5
• PRKM7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical bioactivity profile	1
molecular function	0.99
biological term	0.89
small molecule	0.89

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Mitogen-activated Protein Kinase 7

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Mapk Family / Erk Subfamily / Mitogen-activated Protein Kinase 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.67   (req: < 5)

Gene RIFs: 168   (req: <= 3)

Antibodies: 563   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.67   (req: >= 5)

Gene RIFs: 168   (req: > 3)

Antibodies: 563   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0