AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Protein Summary
Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor. The protein encoded by this gene is part of the aminoacyl-tRNA synthetase complex, which contains nine different aminoacyl-tRNA synthetases and three non-enzymatic factors. The encoded protein is one of the non-enzymatic factors and is required for assembly and stability of the complex. [provided by RefSeq, May 2016]
- ENST00000223029
- ENSP00000223029
- ENSG00000106305
- ENST00000395236
- ENSP00000378658
- JTV1
- P38
- JTV1
- HLD17
- JTV-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
disease perturbation | 0.96 | ||
kinase perturbation | 0.96 | ||
interacting protein | 0.92 | ||
histone modification site profile | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.09 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 186 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.09 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 186 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0