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Tchem
PAK1
Serine/threonine-protein kinase PAK 1

Protein Summary
Description
Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases. Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes. Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton. Plays a role in the regulation of insulin secretion in response to elevated glucose levels. Part of a ternary complex that contains PAK1, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278568
  • ENSP00000278568
  • ENSG00000149269
  • ENST00000356341
  • ENSP00000348696

Symbol
  • IDDMSSD
  • PAKalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase
1
biological term
0.99
kinase perturbation
0.99


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.79   (req: < 5)
Gene RIFs: 250   (req: <= 3)
Antibodies: 1316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.79   (req: >= 5)
Gene RIFs: 250   (req: > 3)
Antibodies: 1316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 90
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 1
VGNC:48940
451439
Macaque
p21 (RAC1) activated kinase 1
698585
Mouse
MGI:1339975
18479
Rat
RGD:3250
29431
Dog
p21 (RAC1) activated kinase 1
VGNC:52285
607885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
p21 (RAC1) activated kinase 1
Macaque
p21 (RAC1) activated kinase 1
Mouse
Rat
Dog
p21 (RAC1) activated kinase 1
Protein Structure (30 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13153-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (124)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Adaptive Immune System
Axon guidance
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Gene Ontology Terms (63)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (273)
1 – 10 of 273
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999999982
p_ni: 1.8e-8
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.999999877
p_ni: 1.23e-7
Data Source: BioPlex
ARHGEF6
Tbio
Novelty: 0.02162737
p_int: 0.999998822
p_ni: 0.000001178
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.999998355
p_ni: 0.000001646
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999997753
p_ni: 0.000002247
Data Source: BioPlex
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999994297
p_ni: 0.000005703
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
p_int: 0.999979591
p_ni: 0.000020409
Score: 0.353
Data Source: BioPlex,STRINGDB
FBXO28
Tbio
Novelty: 0.10548865
p_int: 0.999542148
p_ni: 0.000457852
Score: 0.573
Data Source: BioPlex,STRINGDB
TAS2R41
Tdark
Family: GPCR
Novelty: 0.56248837
p_int: 0.999539955
p_ni: 0.000442458
p_wrong: 0.000017587
Score: 0.219
Data Source: BioPlex,STRINGDB
LPXN
Tbio
Novelty: 0.00796678
p_int: 0.994747911
p_ni: 0.005252089
Score: 0.367
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  300.79

PubMed score by year
PubTator Score  417.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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