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Tchem
TARDBP
TAR DNA-binding protein 43

Protein Summary
Description
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcription ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240185
  • ENSP00000240185
  • ENSG00000120948
  • ENST00000639083
  • ENSP00000491203

Symbol
  • TDP43
  • ALS10
  • TDP-43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
transcription factor perturbation
0.99
disease perturbation
0.96
biological process
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.59   (req: < 5)
Gene RIFs: 501   (req: <= 3)
Antibodies: 873   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 731.59   (req: >= 5)
Gene RIFs: 501   (req: > 3)
Antibodies: 873   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (215)
NCF2
Tbio
Novelty:  0.00274685
p_int:  0.999433409
p_ni:  0.000566589
p_wrong:  2e-9
Score:  0.288
Data Source:  BioPlex,STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
p_int:  0.902959726
p_ni:  0.097040274
Score:  0.189
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.858940585
p_ni:  0.141059415
Data Source:  BioPlex
EPHA2
Tclin
Family:  Kinase
Novelty:  0.00191002
p_int:  0.753822107
p_ni:  0.246177893
Score:  0.202
Data Source:  BioPlex,STRINGDB
HNRNPK
Tbio
Novelty:  0.00354731
Score:  0.986
Data Source:  STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.981
Data Source:  STRINGDB
HNRNPA2B1
Tbio
Novelty:  0.00404935
Score:  0.973
Data Source:  STRINGDB
MATR3
Tbio
Novelty:  0.01218438
Score:  0.971
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.97
Data Source:  STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
Focal Adhesion
WikiPathways
miRNA regulation of p53 pathway in prostate cancer
WikiPathways
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
Name
Explore in Pharos
Explore in Source
MECP2 and Associated Rett Syndrome
MECP2 and Associated Rett Syndrome
Focal Adhesion
miRNA regulation of p53 pathway in prostate cancer
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
4
4
97.2
balding measurement
2
2
2
95.8
3
3
1
1.3
95.7
corneal topography
4
2
4
92.6
heel bone mineral density
2
2
2
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
97.2
balding measurement
2
95.8
1
1.3
95.7
corneal topography
4
92.6
heel bone mineral density
2
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TAR DNA binding protein
VGNC:10944
107974879
Macaque
TAR DNA binding protein
100423163
Mouse
MGI:2387629
230908
Rat
RGD:1310906
298648
Dog
TAR DNA binding protein
VGNC:47109
478234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TAR DNA binding protein
Macaque
TAR DNA binding protein
Mouse
Rat
Dog
TAR DNA binding protein
Publication Statistics
PubMed Score 731.59
PubMed score by year
PubTator Score 1405.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title