You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BAMBI
BMP and activin membrane-bound inhibitor homolog

Protein Summary
Description
Negatively regulates TGF-beta signaling. This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375533
  • ENSP00000364683
  • ENSG00000095739

Symbol
  • NMA
  • NMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
gene perturbation
0.9
transcription factor binding site profile
0.9
biological process
0.84
small molecule perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.26   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.26   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (12)
Downregulation of TGF-beta receptor signaling (R-HSA-2173788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Signal Transduction
Reactome
Signaling by TGF-beta Receptor Complex
Reactome
Signaling by TGF-beta family members
Reactome
TGF-beta receptor signaling activates SMADs
Name
Explore in Pharos
Explore in Source
Downregulation of TGF-beta receptor signaling
Signal Transduction
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta family members
TGF-beta receptor signaling activates SMADs
Protein-Protein Interactions (74)
1 – 10 of 74
BMP4
Tchem
Novelty: 0.00057391
Score: 0.974
Data Source: STRINGDB
BMP7
Tbio
Novelty: 0.000658
Score: 0.972
Data Source: STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00137901
Score: 0.97
Data Source: Reactome,STRINGDB
CHRD
Tbio
Novelty: 0.00426792
Score: 0.966
Data Source: STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00472897
Score: 0.959
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00099344
Score: 0.959
Data Source: Reactome,STRINGDB
BMPR1B
Tchem
Family: Kinase
Novelty: 0.00996192
Score: 0.954
Data Source: STRINGDB
GREM1
Tbio
Novelty: 0.00109982
Score: 0.954
Data Source: STRINGDB
FST
Tbio
Novelty: 0.00081807
Score: 0.954
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.00131071
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  160.26

PubMed score by year
PubTator Score  57.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: