You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BAMBI
BMP and activin membrane-bound inhibitor homolog

Protein Summary
Description
Negatively regulates TGF-beta signaling. This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375533
  • ENSP00000364683
  • ENSG00000095739

Symbol
  • NMA
  • NMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
gene perturbation
0.9
transcription factor binding site profile
0.9
biological process
0.84
small molecule perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.94   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.94   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
24.3
alkaline phosphatase measurement
1
1
1
10.4
heel bone mineral density
1
1
1
9
mean corpuscular volume
1
1
1
8.4
diastolic blood pressure
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
24.3
alkaline phosphatase measurement
1
10.4
heel bone mineral density
1
9
mean corpuscular volume
1
8.4
diastolic blood pressure
1
7.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BMP and activin membrane bound inhibitor
VGNC:11665
745034
Macaque
BMP and activin membrane bound inhibitor
710152
Mouse
MGI:1915260
68010
Rat
RGD:621831
83837
Dog
BMP and activin membrane bound inhibitor
VGNC:38376
487081
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BMP and activin membrane bound inhibitor
Macaque
BMP and activin membrane bound inhibitor
Mouse
Rat
Dog
BMP and activin membrane bound inhibitor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13145-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Downregulation of TGF-beta receptor signaling (R-HSA-2173788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Signal Transduction
Reactome
Signaling by TGF-beta Receptor Complex
Reactome
Signaling by TGF-beta family members
Reactome
TGF-beta receptor signaling activates SMADs
Name
Explore in Pharos
Explore in Source
Downregulation of TGF-beta receptor signaling
Signal Transduction
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta family members
TGF-beta receptor signaling activates SMADs
Protein-Protein Interactions (74)
1 – 10 of 74
BMP4
Tchem
Novelty:  0.00047387
Score:  0.974
Data Source:  STRINGDB
BMP7
Tbio
Novelty:  0.00049424
Score:  0.972
Data Source:  STRINGDB
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
Score:  0.97
Data Source:  Reactome,STRINGDB
CHRD
Tbio
Novelty:  0.00347659
Score:  0.966
Data Source:  STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
Score:  0.959
Data Source:  STRINGDB
TGFBR1
Tchem
Family:  Kinase
Novelty:  0.00081645
Score:  0.959
Data Source:  Reactome,STRINGDB
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
Score:  0.954
Data Source:  STRINGDB
GREM1
Tbio
Novelty:  0.00069784
Score:  0.954
Data Source:  STRINGDB
FST
Tbio
Novelty:  0.00085875
Score:  0.954
Data Source:  STRINGDB
NOG
Tbio
Novelty:  0.0010373
Score:  0.953
Data Source:  STRINGDB
Publication Statistics
PubMed Score  158.94

PubMed score by year
PubTator Score  57.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: