Tbio EIF2B5 Translation initiation factor eIF-2B subunit epsilon

Protein Summary

Description

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q13144
• Q541Z1
• Q96D04

Gene Name

• EIF2B5

Ensembl ID

• ENST00000273783
• ENSP00000273783
• ENSG00000145191
• ENST00000648915
• ENSP00000497160

Symbol

• EIF2BE
• CLE
• CACH
• LVWM
• EIF-2B
• EIF2Bepsilon

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
disease perturbation	0.93
transcription factor binding site profile	0.89
kinase perturbation	0.88
histone modification site profile	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.78   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 151   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.78   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0