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Tbio
EIF2B5
Translation initiation factor eIF-2B subunit epsilon

Protein Summary
Description
Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273783
  • ENSP00000273783
  • ENSG00000145191
  • ENST00000648915
  • ENSP00000497160

Symbol
  • EIF2BE
  • CLE
  • CACH
  • LVWM
  • EIF-2B
  • EIF2Bepsilon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
disease perturbation
0.93
transcription factor binding site profile
0.89
kinase perturbation
0.88
histone modification site profile
0.86


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.26   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.26   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit epsilon
VGNC:6204
460881
Macaque
eukaryotic translation initiation factor 2B subunit epsilon
703673
Mouse
MGI:2446176
224045
Rat
RGD:708380
192234
Dog
eukaryotic translation initiation factor 2B subunit epsilon
VGNC:40264
100856343
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 2B subunit epsilon
Macaque
eukaryotic translation initiation factor 2B subunit epsilon
Mouse
Rat
Dog
eukaryotic translation initiation factor 2B subunit epsilon
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13144-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cap-dependent Translation Initiation (R-HSA-72737)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
Metabolism of proteins
Reactome
Recycling of eIF2:GDP
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
Metabolism of proteins
Recycling of eIF2:GDP
Translation
Protein-Protein Interactions (137)
1 – 10 of 137
CAMSAP2
Tbio
Novelty: 0.07782303
p_int: 0.999999975
p_ni: 2.5e-8
Data Source: BioPlex
INCENP
Tbio
Novelty: 0.00704937
p_int: 0.999999878
p_ni: 1.22e-7
Data Source: BioPlex
EIF2B3
Tbio
Novelty: 0.04963646
p_int: 0.999997689
p_ni: 0.000002311
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF2B2
Tbio
Novelty: 0.03253919
p_int: 0.999996886
p_ni: 0.000003112
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
EIF2B4
Tbio
Novelty: 0.05080792
p_int: 0.999996792
p_ni: 0.000003208
Score: 0.999
Data Source: BioPlex,STRINGDB
ASH1L
Tbio
Family: Epigenetic
Novelty: 0.02897328
p_int: 0.99999075
p_ni: 0.00000925
Data Source: BioPlex
MIS18BP1
Tbio
Novelty: 0.05688807
p_int: 0.999968409
p_ni: 0.000030905
p_wrong: 6.86e-7
Data Source: BioPlex
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
p_int: 0.999958735
p_ni: 0.000041264
Data Source: BioPlex
TTC3
Tbio
Family: Enzyme
Novelty: 0.03120223
p_int: 0.999947724
p_ni: 0.000051271
p_wrong: 0.000001005
Data Source: BioPlex
GPR183
Tchem
Family: GPCR
Novelty: 0.02005679
p_int: 0.999858056
p_ni: 0.000141944
Score: 0.264
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  101.26

PubMed score by year
PubTator Score  53.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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