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Tbio
PPFIA1
Liprin-alpha-1

Protein Summary
Description
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253925
  • ENSP00000253925
  • ENSG00000131626
  • ENST00000389547
  • ENSP00000374198

Symbol
  • LIP1
  • LIP1
  • LIP.1
  • LIPRIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.79
cell line
0.78
protein domain
0.73
histone modification site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.67   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.67   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
NF2
Tbio
Novelty:  0.00055092
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.206
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999997142
p_ni:  0.000002858
Data Source:  BioPlex
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.999996242
p_ni:  0.000003758
Data Source:  BioPlex
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999994232
p_ni:  0.000005768
Score:  0.322
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999992258
p_ni:  0.000007735
p_wrong:  7e-9
Score:  0.876
Data Source:  BioPlex,STRINGDB
CYP4X1
Tbio
Novelty:  0.0592312
p_int:  0.999925943
p_ni:  0.000074057
Score:  0.394
Data Source:  BioPlex,STRINGDB
IL17RE
Tbio
Novelty:  0.07568341
p_int:  0.999781607
p_ni:  0.000218393
Data Source:  BioPlex
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.999670257
p_ni:  0.000329743
Score:  0.158
Data Source:  BioPlex,STRINGDB
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999334622
p_ni:  0.000665378
Score:  0.302
Data Source:  BioPlex,STRINGDB
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.998741362
p_ni:  0.001258638
Score:  0.161
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
65.3
aortic root size
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
65.3
aortic root size
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PTPRF interacting protein alpha 1
VGNC:7660
451390
Macaque
PTPRF interacting protein alpha 1
708387
Mouse
MGI:1924750
233977
Rat
RGD:1309009
293645
Dog
PTPRF interacting protein alpha 1
VGNC:44843
475999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PTPRF interacting protein alpha 1
Macaque
PTPRF interacting protein alpha 1
Mouse
Rat
Dog
PTPRF interacting protein alpha 1
Publication Statistics
PubMed Score 55.67
PubMed score by year
PubTator Score 34.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title