Protein Summary
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- ENST00000253925
- ENSP00000253925
- ENSG00000131626
- ENST00000389547
- ENSP00000374198
- LIP1
- LIP1
- LIP.1
- LIPRIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.91 | ||
disease perturbation | 0.79 | ||
cell line | 0.78 | ||
protein domain | 0.73 | ||
histone modification site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.67 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 177 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.67 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 177 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (114)
NF2
Novelty: 0.00055092
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
PPP2CB
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999994232
p_ni: 0.000005768
Score: 0.322
Data Source: BioPlex,STRINGDB
PPP2R1A
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999992258
p_ni: 0.000007735
p_wrong: 7e-9
Score: 0.876
Data Source: BioPlex,STRINGDB
CYP4X1
Novelty: 0.0592312
p_int: 0.999925943
p_ni: 0.000074057
Score: 0.394
Data Source: BioPlex,STRINGDB
C16orf70
Novelty: 2.12573065
p_int: 0.999670257
p_ni: 0.000329743
Score: 0.158
Data Source: BioPlex,STRINGDB
DTNB
Novelty: 0.0586565
p_int: 0.999334622
p_ni: 0.000665378
Score: 0.302
Data Source: BioPlex,STRINGDB
LLGL2
Novelty: 0.07084531
p_int: 0.998741362
p_ni: 0.001258638
Score: 0.161
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Acetylcholine Neurotransmitter Release Cycle | ||||
Reactome | Dopamine Neurotransmitter Release Cycle | ||||
Reactome | Glutamate Neurotransmitter Release Cycle | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter release cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Acetylcholine Neurotransmitter Release Cycle | ||||
Dopamine Neurotransmitter Release Cycle | ||||
Glutamate Neurotransmitter Release Cycle | ||||
Neuronal System | ||||
Neurotransmitter release cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ParkinsonsUK-UCL | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 2 | 2 | 65.3 | |||||
aortic root size | 1 | 1 | 1 | 33.1 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 65.3 | |||||
aortic root size | 1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | PTPRF interacting protein alpha 1 | VGNC:7660 | 451390 | |||||
Macaque | PTPRF interacting protein alpha 1 | 708387 | ||||||
Mouse | MGI:1924750 | 233977 | ||||||
Rat | RGD:1309009 | 293645 | ||||||
Dog | PTPRF interacting protein alpha 1 | VGNC:44843 | 475999 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | PTPRF interacting protein alpha 1 | |||||
Macaque | PTPRF interacting protein alpha 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | PTPRF interacting protein alpha 1 | |||||
Publication Statistics
PubMed Score 55.67
PubMed score by year
PubTator Score 34.81
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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