Tbio PPFIA1 Liprin-alpha-1

Protein Summary

Description

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13136
• A6NLE3
• Q13135
• Q14567
• Q8N4I2

Gene Name

• PPFIA1

Ensembl ID

• ENST00000253925
• ENSP00000253925
• ENSG00000131626
• ENST00000389547
• ENSP00000374198

Symbol

• LIP1
• LIP1
• LIP.1
• LIPRIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
disease perturbation	0.79
cell line	0.78
protein domain	0.73
histone modification site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.67   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.67   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (114)

Explore Interacting Targets

1 – 10 of 114

• See Interactions on String-DB

NF2

Tbio

Novelty:  0.00055092

p_int:  0.999999974

p_ni:  2.6e-8

Score:  0.206

Data Source:  BioPlex,STRINGDB

BRK1

Tbio

Novelty:  0.02289534

p_int:  0.999997142

p_ni:  0.000002858

Data Source:  BioPlex

GPS2

Tbio

Novelty:  0.00986158

p_int:  0.999996242

p_ni:  0.000003758

Data Source:  BioPlex

PPP2CB

Tbio

Family:  Enzyme

Novelty:  0.0483178

p_int:  0.999994232

p_ni:  0.000005768

Score:  0.322

Data Source:  BioPlex,STRINGDB

PPP2R1A

Tbio

Family:  Enzyme

Novelty:  0.01134139

p_int:  0.999992258

p_ni:  0.000007735

p_wrong:  7e-9

Score:  0.876

Data Source:  BioPlex,STRINGDB

CYP4X1

Tbio

Novelty:  0.0592312

p_int:  0.999925943

p_ni:  0.000074057

Score:  0.394

Data Source:  BioPlex,STRINGDB

IL17RE

Tbio

Novelty:  0.07568341

p_int:  0.999781607

p_ni:  0.000218393

Data Source:  BioPlex

C16orf70

Tdark

Novelty:  2.12573065

p_int:  0.999670257

p_ni:  0.000329743

Score:  0.158

Data Source:  BioPlex,STRINGDB

DTNB

Tbio

Novelty:  0.0586565

p_int:  0.999334622

p_ni:  0.000665378

Score:  0.302

Data Source:  BioPlex,STRINGDB

LLGL2

Tbio

Novelty:  0.07084531

p_int:  0.998741362

p_ni:  0.001258638

Score:  0.161

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (10)

Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Acetylcholine Neurotransmitter Release Cycle	17 targets	R-HSA-264642
Reactome	Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
Reactome	Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Neurotransmitter release cycle	51 targets	R-HSA-112310

Name	Explore in Pharos	Explore in Source
Acetylcholine Neurotransmitter Release Cycle	17 targets	R-HSA-264642
Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Neuronal System	398 targets	R-HSA-112316
Neurotransmitter release cycle	51 targets	R-HSA-112310

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (4)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	HPA
focal adhesion	Inferred from Direct Assay (IDA)	HPA
cytoplasm	Traceable Author Statement (TAS)	ProtInc
presynaptic active zone	Traceable Author Statement (TAS)	ParkinsonsUK-UCL

Disease Associations ()

No disease associations found

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	2	2	2		65.3
aortic root size	EFO_0005037	1	1	1		33.1

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1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	2		65.3
aortic root size	EFO_0005037	1		33.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
aortic root size
lymphocyte count

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	PTPRF interacting protein alpha 1	VGNC:7660	451390
Macaque	PTPRF interacting protein alpha 1		708387
Mouse	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	MGI:1924750	233977
Rat	PTPRF interacting protein alpha 1	RGD:1309009	293645
Dog	PTPRF interacting protein alpha 1	VGNC:44843	475999

Species	Name	OMA	EggNOG	Inparanoid
Chimp	PTPRF interacting protein alpha 1
Macaque	PTPRF interacting protein alpha 1
Mouse	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Rat	PTPRF interacting protein alpha 1
Dog	PTPRF interacting protein alpha 1

Publication Statistics

PubMed Score 55.67

PubMed score by year

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PubTator Score 34.81

PubTator score by year

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Related Publications

Text Mined References (36)

GeneRif Annotations (19)

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PMID	Year	Title