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Tchem
NR1H3
Oxysterols receptor LXR-alpha

Protein Summary
Description
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involve ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395397
  • ENSP00000378793
  • ENSG00000025434
  • ENST00000405853
  • ENSP00000384745
  • ENST00000407404
  • ENSP00000385801
  • ENST00000441012
  • ENSP00000387946
  • ENST00000467728
  • ENSP00000420656

Symbol
  • LXRA
  • LXRA
  • LXR-a
  • RLD-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.98
disease perturbation
0.87
transcription factor binding site profile
0.87
cell type or tissue
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.69   (req: < 5)
Gene RIFs: 228   (req: <= 3)
Antibodies: 530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.69   (req: >= 5)
Gene RIFs: 228   (req: > 3)
Antibodies: 530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 261
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
3
92.8
1
1
1
85.5
unipolar depression
1
1
1
85.5
triglyceride measurement
2
2
2
77.7
intraocular pressure measurement
1
1
1
73.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
92.8
1
85.5
unipolar depression
1
85.5
triglyceride measurement
2
77.7
intraocular pressure measurement
1
73.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group H member 3
VGNC:3089
466507
Mouse
MGI:1352462
22259
Rat
RGD:61909
58852
Dog
nuclear receptor subfamily 1 group H member 3
VGNC:43943
483625
Horse
nuclear receptor subfamily 1 group H member 3
VGNC:20861
100051253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group H member 3
Mouse
Rat
Dog
nuclear receptor subfamily 1 group H member 3
Horse
nuclear receptor subfamily 1 group H member 3
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13133-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Metabolism of proteins
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (118)
1 – 10 of 118
DDI2
Tbio
Novelty: 0.09288646
p_int: 0.998609285
p_ni: 0.001390715
Score: 0.528
Data Source: BioPlex,STRINGDB
PDE8A
Tclin
Family: Enzyme
Novelty: 0.04254335
p_int: 0.974731562
p_ni: 0.000048516
p_wrong: 0.025219921
Score: 0.359
Data Source: BioPlex,STRINGDB
STRN4
Tbio
Novelty: 0.09936184
p_int: 0.972102344
p_ni: 0.027897651
p_wrong: 5e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
STRN
Tbio
Novelty: 0.01025814
p_int: 0.959271937
p_ni: 0.040728063
Score: 0.234
Data Source: BioPlex,STRINGDB
STRN3
Tbio
Novelty: 0.10331283
p_int: 0.770491535
p_ni: 0.229508465
Score: 0.201
Data Source: BioPlex,STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.993
Data Source: Reactome,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
Score: 0.988
Data Source: Reactome,STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.987
Data Source: Reactome,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.986
Data Source: Reactome,STRINGDB
ABCA1
Tclin
Family: Transporter
Novelty: 0.00059241
Score: 0.985
Data Source: STRINGDB
Publication Statistics
PubMed Score  192.69

PubMed score by year
PubTator Score  347.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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