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Tchem
NR1H3
Oxysterols receptor LXR-alpha

Protein Summary
Description
Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involve ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395397
  • ENSP00000378793
  • ENSG00000025434
  • ENST00000405853
  • ENSP00000384745
  • ENST00000407404
  • ENSP00000385801
  • ENST00000441012
  • ENSP00000387946
  • ENST00000467728
  • ENSP00000420656

Symbol
  • LXRA
  • LXRA
  • LXR-a
  • RLD-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.98
disease perturbation
0.87
transcription factor binding site profile
0.87
cell type or tissue
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.03   (req: < 5)
Gene RIFs: 228   (req: <= 3)
Antibodies: 530   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.03   (req: >= 5)
Gene RIFs: 228   (req: > 3)
Antibodies: 530   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 281
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0