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Tclin
PRKAA1
5'-AMP-activated protein kinase catalytic subunit alpha-1

Protein Summary
Description
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphoryl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354209
  • ENSP00000346148
  • ENSG00000132356
  • ENST00000397128
  • ENSP00000380317

Symbol
  • AMPK1
  • AMPK
  • AMPKa1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical bioactivity profile
1
drug perturbation
1
interacting protein
1
molecular function
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.22   (req: < 5)
Gene RIFs: 326   (req: <= 3)
Antibodies: 1299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.22   (req: >= 5)
Gene RIFs: 326   (req: > 3)
Antibodies: 1299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 71
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
0
1.3
98.5
gastric cardia carcinoma
1
1
0
1.2
78.4
mean corpuscular hemoglobin concentration
1
1
1
56.9
reticulocyte measurement
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
98.5
gastric cardia carcinoma
0
1.2
78.4
mean corpuscular hemoglobin concentration
1
56.9
reticulocyte measurement
1
21
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (73)
Activation of AMPK downstream of NMDARs (R-HSA-9619483)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Name
Explore in Pharos
Explore in Source
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene Ontology Terms (81)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (198)
1 – 10 of 198
PRKAG1
Tbio
Family: Kinase
Novelty: 0.07735301
p_int: 0.999999824
p_ni: 1.76e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRKAB2
Tchem
Family: Enzyme
Novelty: 0.02815065
p_int: 0.999999711
p_ni: 2.89e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRKAB1
Tchem
Family: Kinase
Novelty: 0.01610606
p_int: 0.999999663
p_ni: 3.37e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRKAG2
Tbio
Family: Enzyme
Novelty: 0.00741608
p_int: 0.999995732
p_ni: 0.000004268
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
MID1IP1
Tbio
Novelty: 0.11443752
p_int: 0.999959821
p_ni: 0.000040179
Data Source: BioPlex
PRKAG3
Tbio
Family: Enzyme
Novelty: 0.01865144
p_int: 0.999955461
p_ni: 0.000044539
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
STIM2
Tbio
Novelty: 0.00446493
p_int: 0.999941769
p_ni: 0.000058231
Score: 0.828
Data Source: BioPlex,STRINGDB
PHKG2
Tchem
Family: Kinase
Novelty: 0.064884
p_int: 0.999937294
p_ni: 0.000062706
Score: 0.708
Data Source: BioPlex,STRINGDB
POLR3K
Tbio
Family: Enzyme
Novelty: 0.07105011
p_int: 0.999802163
p_ni: 0.000197837
Data Source: BioPlex
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.998877618
p_ni: 0.001122382
Score: 0.902
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  72.22

PubMed score by year
PubTator Score  727.58

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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