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Tbio
REST
RE1-silencing transcription factor

Protein Summary
Description
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309042
  • ENSP00000311816
  • ENSG00000084093
  • ENST00000619101
  • ENSP00000484836

Symbol
  • NRSF
  • XBR
  • WT6
  • XBR
  • HGF5
  • NRSF
  • DFNA27
  • GINGF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
virus perturbation
0.94
biological term
0.89
transcription factor binding site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.86   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.86   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
3
5
91.1
mean platelet volume
3
3
3
89.1
platelet count
4
3
4
85.3
5
5
3
1.1
83.5
mean corpuscular volume
1
2
2
77.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
5
91.1
mean platelet volume
3
89.1
platelet count
4
85.3
3
1.1
83.5
mean corpuscular volume
2
77.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RE1 silencing transcription factor
VGNC:8271
471235
Macaque
RE1 silencing transcription factor
100425257
Mouse
MGI:104897
19712
Rat
RGD:621069
83618
Dog
RE1 silencing transcription factor
VGNC:45480
482163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RE1 silencing transcription factor
Macaque
RE1 silencing transcription factor
Mouse
Rat
Dog
RE1 silencing transcription factor
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13127-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDACs deacetylate histones
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDACs deacetylate histones
Intracellular signaling by second messengers
PIP3 activates AKT signaling
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (132)
1 – 10 of 132
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
Score:  0.992
Data Source:  Reactome,STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
Score:  0.982
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.972
Data Source:  Reactome,STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.961
Data Source:  Reactome,STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.96
Data Source:  Reactome,STRINGDB
HTT
Tchem
Novelty:  0.00034051
Score:  0.951
Data Source:  STRINGDB
HDAC5
Tclin
Family:  Epigenetic
Novelty:  0.00484422
Score:  0.949
Data Source:  STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.947
Data Source:  STRINGDB
NR2E1
Tbio
Family:  NR
Novelty:  0.0184868
Score:  0.939
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.935
Data Source:  STRINGDB
Publication Statistics
PubMed Score  379.86

PubMed score by year
PubTator Score  315.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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