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Tbio
REST
RE1-silencing transcription factor

Protein Summary
Description
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309042
  • ENSP00000311816
  • ENSG00000084093
  • ENST00000619101
  • ENSP00000484836

Symbol
  • NRSF
  • XBR
  • WT6
  • XBR
  • HGF5
  • NRSF
  • DFNA27
  • GINGF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
virus perturbation
0.94
biological term
0.89
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.72   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.72   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDACs deacetylate histones
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDACs deacetylate histones
Intracellular signaling by second messengers
PIP3 activates AKT signaling
Gene Ontology Terms (46)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (132)
1 – 10 of 132
RCOR1
Tbio
Family: TF
Novelty: 0.00972564
Score: 0.992
Data Source: Reactome,STRINGDB
SIN3B
Tbio
Novelty: 0.04173216
Score: 0.982
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00083441
Score: 0.972
Data Source: Reactome,STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.00143918
Score: 0.961
Data Source: Reactome,STRINGDB
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00170368
Score: 0.96
Data Source: Reactome,STRINGDB
HTT
Tchem
Novelty: 0.00040613
Score: 0.951
Data Source: STRINGDB
HDAC5
Tclin
Family: Epigenetic
Novelty: 0.00560014
Score: 0.949
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00057242
Score: 0.947
Data Source: STRINGDB
NR2E1
Tbio
Family: NR
Novelty: 0.02124787
Score: 0.939
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  347.72

PubMed score by year
PubTator Score  315.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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