Tchem MTAP S-methyl-5'-thioadenosine phosphorylase

Protein Summary

Description

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13126
• I2G7M5
• I2G7M6
• I2G7M7
• I2G7M8
• I2G7M9
• I2G7N0
• Q5T3P3
• Q9H010

Gene Name

• MTAP

Ensembl ID

• ENST00000380172
• ENSP00000369519
• ENSG00000099810
• ENST00000580900
• ENSP00000463424
• ENST00000644715
• ENSP00000494373

Symbol

• MSAP
• BDMF
• MSAP
• DMSFH
• LGMBF
• DMSMFH
• c86fus
• HEL-249

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor perturbation	0.97
kinase perturbation	0.84
biological process	0.74
disease	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Phosphorylase / S-methyl-5'-thioadenosine Phosphorylase

DTO Classes

Protein / Enzyme / Transferase / Phosphorylase / S-methyl-5'-thioadenosine Phosphorylase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.29   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 235   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.29   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 78

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0