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Tbio
IK
Protein Red

Protein Summary
Description
Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression (PubMed:22351768, PubMed:24252166). Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint (PubMed:22351768). Required for normal accumulation of SMU1 (PubMed:24945353). (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its functi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417647
  • ENSP00000396301
  • ENSG00000113141

Symbol
  • RED
  • RER
  • RED
  • RER
  • CSA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
interacting protein
0.97
histone modification site profile
0.83
kinase perturbation
0.76
tissue sample
0.7


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.14   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.14   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
IK cytokine
696887
Mouse
MGI:1345142
24010
Rat
RGD:1359352
291659
Dog
IK cytokine
607109
Cow
IK cytokine
VGNC:30100
100125318
Species
Name
OMA
EggNOG
Inparanoid
Macaque
IK cytokine
Mouse
Rat
Dog
IK cytokine
Cow
IK cytokine
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13123-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (105)
1 – 10 of 105
SMU1
Tbio
Novelty: 0.02232467
p_int: 0.999999996
p_ni: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.999892364
p_ni: 0.000107636
Data Source: BioPlex
FKBP6
Tbio
Family: Enzyme
Novelty: 0.02240256
p_int: 0.998390313
p_ni: 0.001609687
Score: 0.225
Data Source: BioPlex,STRINGDB
DDX23
Tbio
Family: Enzyme
Novelty: 0.03592096
p_int: 0.996547428
p_ni: 0.003452572
Score: 0.263
Data Source: BioPlex,STRINGDB
MRFAP1
Tbio
Novelty: 0.11341713
p_int: 0.993496121
p_ni: 0.006503878
Data Source: BioPlex
TSSC4
Tdark
Novelty: 0.17064786
p_int: 0.992728909
p_ni: 0.007271091
Score: 0.205
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.97934031
p_ni: 0.02065969
Data Source: BioPlex
LOXL2
Tbio
Family: Enzyme
Novelty: 0.00599536
p_int: 0.977010252
p_ni: 0.022989742
p_wrong: 6e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
LUC7L2
Tdark
Novelty: 0.36989457
p_int: 0.940408909
p_ni: 0.059590677
p_wrong: 4.14e-7
Data Source: BioPlex
DUSP23
Tbio
Family: Enzyme
Novelty: 0.06522366
p_int: 0.902498595
p_ni: 0.097501359
p_wrong: 4.6e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  62.14

PubMed score by year
PubTator Score  96.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer