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Tbio
KLF10
Krueppel-like factor 10

Protein Summary
Description
Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis (By similarity). May play a role in the cell cycle regulation. This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285407
  • ENSP00000285407
  • ENSG00000155090
  • ENST00000395884
  • ENSP00000379222

Symbol
  • TIEG
  • TIEG1
  • EGRA
  • TIEG
  • TIEG1
  • EGR-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
transcription factor binding site profile
0.96
disease perturbation
0.93
biological process
0.9
small molecule perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.24   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.24   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.795
Data Source:  STRINGDB
KDM5B
Tchem
Family:  TF; Epigenetic
Novelty:  0.00610414
Score:  0.751
Data Source:  STRINGDB
SIN3A
Tbio
Novelty:  0.00747207
Score:  0.659
Data Source:  STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.633
Data Source:  STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
Score:  0.617
Data Source:  STRINGDB
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
Score:  0.583
Data Source:  STRINGDB
ITCH
Tbio
Family:  Enzyme
Novelty:  0.00681861
Score:  0.571
Data Source:  STRINGDB
RUNX2
Tbio
Family:  TF
Novelty:  0.00028804
Score:  0.569
Data Source:  STRINGDB
MLXIPL
Tbio
Family:  TF
Novelty:  0.00357389
Score:  0.542
Data Source:  STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
Score:  0.54
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
1
1
8.4
68.6
urate measurement
2
2
2
60.9
serum IgM measurement
1
1
1
32.9
mean reticulocyte volume
1
1
1
21
C-reactive protein measurement
1
1
1
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
8.4
68.6
urate measurement
2
60.9
serum IgM measurement
1
32.9
mean reticulocyte volume
1
21
C-reactive protein measurement
1
10.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 10
VGNC:13169
472833
Macaque
Kruppel like factor 10
693458
Mouse
MGI:1101353
21847
Rat
RGD:621652
81813
Dog
Kruppel like factor 10
VGNC:42431
481992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kruppel like factor 10
Macaque
Kruppel like factor 10
Mouse
Rat
Dog
Kruppel like factor 10
Publication Statistics
PubMed Score 138.24
PubMed score by year
PubTator Score 64.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text