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Tbio
DUSP4
Dual specificity protein phosphatase 4

Protein Summary
Description
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isof ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240100
  • ENSP00000240100
  • ENSG00000120875
  • ENST00000240101
  • ENSP00000240101

Symbol
  • MKP2
  • VH2
  • TYP
  • HVH2
  • MKP2
  • MKP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
protein domain
0.97
small molecule perturbation
0.96
transcription factor binding site profile
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.65   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.65   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
ERK/MAPK targets
Reactome
ERKs are inactivated
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
ERK/MAPK targets
ERKs are inactivated
FLT3 Signaling
Immune System
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (65)
1 – 10 of 65
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.986
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.979
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.978
Data Source: Reactome,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.97
Data Source: STRINGDB
MAPK7
Tchem
Family: Kinase
Novelty: 0.00257226
Score: 0.944
Data Source: Reactome,STRINGDB
DUSP6
Tbio
Family: Enzyme
Novelty: 0.00426304
Score: 0.917
Data Source: STRINGDB
DUSP8
Tbio
Family: Enzyme
Novelty: 0.0105002
Score: 0.915
Data Source: STRINGDB
DUSP9
Tbio
Family: Enzyme
Novelty: 0.03849148
Score: 0.911
Data Source: STRINGDB
DUSP2
Tbio
Family: Enzyme
Novelty: 0.03459749
Score: 0.904
Data Source: STRINGDB
DUSP1
Tchem
Family: Enzyme
Novelty: 0.00097955
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.65

PubMed score by year
PubTator Score  79.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer