Tbio CHAF1B Chromatin assembly factor 1 subunit B

Protein Summary

Description

Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13112
• Q99548
• CAF-1 subunit B

Gene Name

• CHAF1B

Ensembl ID

• ENST00000314103
• ENSP00000315700
• ENSG00000159259

Symbol

• CAF1A
• CAF1P60
• MPHOSPH7
• MPP7
• CAF1
• MPP7
• CAF-1
• CAF1A
• CAF1P60
• CAF-IP60
• MPHOSPH7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
transcription factor perturbation	0.84
histone modification site profile	0.83
tissue sample	0.77
interacting protein	0.75

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Chromatin Assembly Factor 1 Subunit B

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Chromatin Assembly Factor 1 Subunit B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.44   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.44   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0