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Tchem
USP4
Ubiquitin carboxyl-terminal hydrolase 4

Protein Summary
Description
Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins (PubMed:16316627, PubMed:16472766, PubMed:16339847, PubMed:20595234, PubMed:22347420, PubMed:25404403). Deubiquitinates PDPK1 (PubMed:22347420). Deubiquitinates TRIM21 (PubMed:16316627). Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface (PubMed:16339847). May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3 (PubMed:20595234). This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP (PubMed:20595234). May also play a role in the regulation of quality control in the ER (PubMed:16339847). The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript vari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265560
  • ENSP00000265560
  • ENSG00000114316
  • ENST00000351842
  • ENSP00000341028
  • ENST00000416417
  • ENSP00000400623

Symbol
  • UNP
  • UNPH
  • UNP
  • Unph
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.97
histone modification site profile
0.87
protein domain
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.51   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.51   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (173)
ELMO1
Tbio
Novelty:  0.01598587
p_int:  0.999993493
p_ni:  0.000006506
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999953768
p_ni:  0.000046225
p_wrong:  6e-9
Data Source:  BioPlex
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.999939541
p_ni:  0.000046405
p_wrong:  0.000014054
Score:  0.16
Data Source:  BioPlex,STRINGDB
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999871333
p_ni:  0.000128667
Score:  0.587
Data Source:  BioPlex,STRINGDB
CABP1
Tbio
Novelty:  0.02097068
p_int:  0.999801314
p_ni:  0.000198686
Score:  0.318
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999789172
p_ni:  0.000210828
Score:  0.735
Data Source:  BioPlex,STRINGDB
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  0.999773676
p_ni:  0.000226322
p_wrong:  2e-9
Data Source:  BioPlex
DCP1B
Tdark
Novelty:  0.36605365
p_int:  0.999741429
p_ni:  0.000258571
Data Source:  BioPlex
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.999633881
p_ni:  0.000365812
p_wrong:  3.06e-7
Data Source:  BioPlex
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.999631557
p_ni:  0.000352587
p_wrong:  0.000015857
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Regulation of TNFR1 signaling
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Deubiquitination
Metabolism of proteins
Post-translational protein modification
Regulation of TNFR1 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
11
4
6.9
95.1
self reported educational attainment
5
5
6
1
92.9
red blood cell distribution width
4
3
4
90.8
household income
1
4
4
90.1
cognitive function measurement
2
1
2
85.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
6.9
95.1
self reported educational attainment
6
1
92.9
red blood cell distribution width
4
90.8
household income
4
90.1
cognitive function measurement
2
85.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 4
VGNC:10047
460367
Macaque
ubiquitin carboxyl-terminal hydrolase 4
706930
Mouse
MGI:98905
22258
Rat
RGD:1587387
290864
Dog
ubiquitin specific peptidase 4
VGNC:48195
476624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin specific peptidase 4
Macaque
ubiquitin carboxyl-terminal hydrolase 4
Mouse
Rat
Dog
ubiquitin specific peptidase 4
Publication Statistics
PubMed Score 105.51
PubMed score by year
PubTator Score 65.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title