Tbio ZBTB17 Zinc finger and BTB domain-containing protein 17

Protein Summary

Description

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13105
• A0AV07
• B4DXB4
• B7ZLQ9
• F5H411
• Q15932
• Q5JYB2
• Q9NUC9

Gene Name

• ZBTB17

Ensembl ID

• ENST00000375733
• ENSP00000364885
• ENSG00000116809
• ENST00000375743
• ENSP00000364895
• ENST00000537142
• ENSP00000438529

Symbol

• MIZ1
• ZNF151
• ZNF60
• MIZ-1
• ZNF60
• ZNF151
• pHZ-67

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
biological process	0.79
disease perturbation	0.74
transcription factor binding site profile	0.71
histone modification site profile	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.3   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.3   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0