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Tbio
ZBTB17
Zinc finger and BTB domain-containing protein 17

Protein Summary
Description
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946). This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375733
  • ENSP00000364885
  • ENSG00000116809
  • ENST00000375743
  • ENSP00000364895
  • ENST00000537142
  • ENSP00000438529

Symbol
  • MIZ1
  • ZNF151
  • ZNF60
  • MIZ-1
  • ZNF60
  • ZNF151
  • pHZ-67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.79
disease perturbation
0.74
transcription factor binding site profile
0.71
histone modification site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.47   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.47   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
92.9
hematocrit
2
2
2
90
hemoglobin measurement
2
2
2
89.1
serum gamma-glutamyl transferase measurement
1
3
3
87.4
3
2
1
1.3
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
92.9
hematocrit
2
90
hemoglobin measurement
2
89.1
serum gamma-glutamyl transferase measurement
3
87.4
1
1.3
78.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 17
VGNC:8123
740453
Macaque
zinc finger and BTB domain containing 17
696327
Mouse
MGI:107410
22642
Rat
RGD:1307143
313666
Dog
zinc finger and BTB domain containing 17
VGNC:48525
607083
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger and BTB domain containing 17
Macaque
zinc finger and BTB domain containing 17
Mouse
Rat
Dog
zinc finger and BTB domain containing 17
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13105-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Gene Ontology Terms (19)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (61)
1 – 10 of 61
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.982
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.955
Data Source:  STRINGDB
IRF8
Tbio
Family:  TF
Novelty:  0.00330143
Score:  0.947
Data Source:  STRINGDB
MAX
Tbio
Family:  TF
Novelty:  0.00799068
Score:  0.946
Data Source:  STRINGDB
DNMT3A
Tclin
Family:  Epigenetic
Novelty:  0.00085974
Score:  0.941
Data Source:  STRINGDB
GFI1
Tbio
Family:  TF
Novelty:  0.00466154
Score:  0.94
Data Source:  STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.925
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.924
Data Source:  STRINGDB
SP1
Tbio
Family:  TF
Novelty:  0.0007915
Score:  0.905
Data Source:  STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.904
Data Source:  STRINGDB
Publication Statistics
PubMed Score  28.47

PubMed score by year
PubTator Score  39.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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