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Tbio
SPP2
Secreted phosphoprotein 24

Protein Summary
Description
Could coordinate an aspect of bone turnover. This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000168148
  • ENSP00000168148
  • ENSG00000072080
  • ENST00000373368
  • ENSP00000362466

Symbol
  • SPP24
  • SPP24
  • SPP-24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.6
gene perturbation
0.59
cell line
0.54
cell type or tissue
0.54
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (179)
AHSG
Tbio
Novelty:  0.00112502
Score:  0.986
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.972
Data Source:  STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.969
Data Source:  STRINGDB
PROC
Tchem
Family:  Enzyme
Novelty:  0.00440723
Score:  0.963
Data Source:  STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.957
Data Source:  STRINGDB
ITIH2
Tbio
Novelty:  0.04886358
Score:  0.956
Data Source:  STRINGDB
ITIH3
Tbio
Novelty:  0.04201144
Score:  0.955
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.947
Data Source:  STRINGDB
SERPINA10
Tbio
Family:  Enzyme
Novelty:  0.01229147
Score:  0.945
Data Source:  STRINGDB
CLEC3B
Tbio
Novelty:  0.0037534
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Metabolism of proteins
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Hemostasis
Metabolism of proteins
Platelet activation, signaling and aggregation
Platelet degranulation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
2
23
43
99.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
43
99.8
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secreted phosphoprotein 2
VGNC:2866
107973975
Macaque
secreted phosphoprotein 2
718239
Mouse
MGI:1922646
75396
Dog
secreted phosphoprotein 2
VGNC:46757
610394
Horse
secreted phosphoprotein 2
VGNC:23534
100065471
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secreted phosphoprotein 2
Macaque
secreted phosphoprotein 2
Mouse
Dog
secreted phosphoprotein 2
Horse
secreted phosphoprotein 2
Publication Statistics
PubMed Score 28.14
PubMed score by year
PubTator Score 36.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title