You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GPS1
COP9 signalosome complex subunit 1

Protein Summary
Description
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306823
  • ENSP00000302873
  • ENSG00000169727
  • ENST00000392358
  • ENSP00000376167
  • ENST00000578552
  • ENSP00000462265

Symbol
  • COPS1
  • CSN1
  • CSN1
  • SGN1
  • COPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
tissue sample
0.68
biological process
0.66
protein complex
0.62
cell line
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.06   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.06   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (261)
COPS8
Tbio
Novelty:  0.0408885
p_int:  0.999998449
p_ni:  0.000001551
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.99997678
p_ni:  0.00002322
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.999944438
p_ni:  0.000055562
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.999915933
p_ni:  0.000084067
Score:  0.999
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.999687285
p_ni:  0.000312715
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANKRD39
Tdark
Novelty:  8.68843298
p_int:  0.997012488
p_ni:  0.002987512
Data Source:  BioPlex
APBB3
Tbio
Novelty:  0.15864948
p_int:  0.983441258
p_ni:  0.016558742
Score:  0.688
Data Source:  BioPlex,STRINGDB
COPS7B
Tbio
Novelty:  0.63421506
p_int:  0.979323957
p_ni:  0.020676043
Score:  0.999
Data Source:  BioPlex,STRINGDB
DCAF4
Tbio
Novelty:  0.24190895
p_int:  0.967895854
p_ni:  0.032104146
Score:  0.968
Data Source:  BioPlex,STRINGDB
KLHL10
Tdark
Novelty:  0.09497583
p_int:  0.96558306
p_ni:  0.03441694
Score:  0.797
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Formation of TC-NER Pre-Incision Complex
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
DNA Damage Recognition in GG-NER
DNA Repair
Formation of TC-NER Pre-Incision Complex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
76.5
vital capacity
1
1
1
73.2
blood metabolite measurement
1
1
1
57.3
BMI-adjusted waist-hip ratio
2
2
2
48.3
forced expiratory volume
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
76.5
vital capacity
1
73.2
blood metabolite measurement
1
57.3
BMI-adjusted waist-hip ratio
2
48.3
forced expiratory volume
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2384801
209318
Rat
RGD:621532
117039
Dog
G protein pathway suppressor 1
VGNC:41455
483377
Horse
G protein pathway suppressor 1
VGNC:18560
100056238
Cow
G protein pathway suppressor 1
VGNC:29612
525572
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
G protein pathway suppressor 1
Horse
G protein pathway suppressor 1
Cow
G protein pathway suppressor 1
Publication Statistics
PubMed Score 70.06
PubMed score by year
PubTator Score 52.71
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title