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Tbio
GPS1
COP9 signalosome complex subunit 1

Protein Summary
Description
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306823
  • ENSP00000302873
  • ENSG00000169727
  • ENST00000392358
  • ENSP00000376167
  • ENST00000578552
  • ENSP00000462265

Symbol
  • COPS1
  • CSN1
  • CSN1
  • SGN1
  • COPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
tissue sample
0.68
biological process
0.66
protein complex
0.62
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.6   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.6   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
DNA Damage Recognition in GG-NER
Reactome
DNA Repair
Reactome
Formation of TC-NER Pre-Incision Complex
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
DNA Damage Recognition in GG-NER
DNA Repair
Formation of TC-NER Pre-Incision Complex
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (261)
1 – 10 of 261
COPS8
Tbio
Novelty: 0.05324769
p_int: 0.999998449
p_ni: 0.000001551
Score: 0.999
Data Source: BioPlex,STRINGDB
COPS2
Tbio
Novelty: 0.09131066
p_int: 0.99997678
p_ni: 0.00002322
Score: 0.999
Data Source: BioPlex,STRINGDB
COPS6
Tbio
Novelty: 0.02901234
p_int: 0.999944438
p_ni: 0.000055562
Score: 0.999
Data Source: BioPlex,STRINGDB
COPS3
Tbio
Novelty: 0.07789318
p_int: 0.999915933
p_ni: 0.000084067
Score: 0.999
Data Source: BioPlex,STRINGDB
COPS5
Tbio
Novelty: 0.00481687
p_int: 0.999687285
p_ni: 0.000312715
Score: 0.999
Data Source: BioPlex,STRINGDB
ANKRD39
Tdark
p_int: 0.997012488
p_ni: 0.002987512
Data Source: BioPlex
APBB3
Tdark
Novelty: 0.21392217
p_int: 0.983441258
p_ni: 0.016558742
Score: 0.688
Data Source: BioPlex,STRINGDB
COPS7B
Tbio
Novelty: 1.26436782
p_int: 0.979323957
p_ni: 0.020676043
Score: 0.999
Data Source: BioPlex,STRINGDB
DCAF4
Tdark
Novelty: 0.32846715
p_int: 0.967895854
p_ni: 0.032104146
Score: 0.968
Data Source: BioPlex,STRINGDB
KLHL10
Tdark
Novelty: 0.18423746
p_int: 0.96558306
p_ni: 0.03441694
Score: 0.797
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  37.60

PubMed score by year
PubTator Score  52.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer