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Tbio
LCP2
Lymphocyte cytosolic protein 2

Protein Classes
Protein Summary
Description
Involved in T-cell antigen receptor mediated signaling. This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000046794
  • ENSP00000046794
  • ENSG00000043462

Symbol
  • SLP76
  • SLP-76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.94
hub protein
0.92
kinase
0.89
PubMedID
0.75
biological term
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.48   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 631   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.48   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 631   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
63.8
eosinophil percentage of leukocytes
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
63.8
eosinophil percentage of leukocytes
1
29
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lymphocyte cytosolic protein 2
VGNC:4067
471734
Macaque
lymphocyte cytosolic protein 2
700374
Mouse
MGI:1321402
16822
Rat
RGD:619743
155918
Dog
lymphocyte cytosolic protein 2
VGNC:42615
489126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lymphocyte cytosolic protein 2
Macaque
lymphocyte cytosolic protein 2
Mouse
Rat
Dog
lymphocyte cytosolic protein 2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (99)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Reactome
FCERI mediated Ca+2 mobilization
Reactome
FCERI mediated MAPK activation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
DAP12 interactions
DAP12 signaling
FCERI mediated Ca+2 mobilization
FCERI mediated MAPK activation
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (344)
1 – 10 of 344
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.998
Data Source: Reactome,STRINGDB
GRAP2
Tbio
Novelty: 0.00503901
Score: 0.998
Data Source: Reactome,STRINGDB
FYB1
Tbio
Novelty: 0.00247573
Score: 0.997
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.997
Data Source: Reactome,STRINGDB
ITK
Tclin
Family: Kinase
Novelty: 0.00054195
Score: 0.996
Data Source: Reactome,STRINGDB
LAT
Tbio
Novelty: 0.00738419
Score: 0.994
Data Source: Reactome,STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.994
Data Source: Reactome,STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.993
Data Source: Reactome,STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00294726
Score: 0.99
Data Source: Reactome,STRINGDB
MAP4K1
Tchem
Family: Kinase
Novelty: 0.02861969
Score: 0.989
Data Source: STRINGDB
Publication Statistics
PubMed Score  203.48

PubMed score by year
PubTator Score  125.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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