Tbio LCP2 Lymphocyte cytosolic protein 2

Protein Summary

Description

Involved in T-cell antigen receptor mediated signaling. This gene encodes an adapter protein that acts as a substrate of the T cell antigen receptor (TCR)-activated protein tyrosine kinase pathway. The encoded protein associates with growth factor receptor bound protein 2, and is thought to play a role TCR-mediated intracellular signal transduction. A similar protein in mouse plays a role in normal T-cell development and activation. Mice lacking this gene show subcutaneous and intraperitoneal fetal hemorrhaging, dysfunctional platelets and impaired viability. [provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• Q13094
• A8KA25
• Q53XV4

Gene Name

• LCP2

Ensembl ID

• ENST00000046794
• ENSP00000046794
• ENSG00000043462

Symbol

• SLP76
• SLP-76

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.94
hub protein	0.92
kinase	0.89
PubMedID	0.75
biological term	0.73

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Lymphocyte Cytosolic Protein 2

DTO Classes

Protein / Signaling / Lymphocyte Cytosolic Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.21   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 631   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.21   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 631   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0