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Tchem
PLA2G7
Platelet-activating factor acetylhydrolase

Protein Classes
Protein Summary
Description
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274793
  • ENSP00000274793
  • ENSG00000146070
  • ENST00000537365
  • ENSP00000445666

Symbol
  • PAFAH
  • PAFAD
  • PAFAH
  • LP-PLA2
  • LDL-PLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
biological term
0.94
kinase perturbation
0.84
gene perturbation
0.77
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.1   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 547.1   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 320
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
orlistat
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
4
4
3
41.9
98.9
acute coronary syndrome
2
1
1
72.8
81.8
2
1
1
72.8
81.8
response to darapladib
1
1
1
77.2
lipoprotein-associated phospholipase A(2) change measurement
1
1
1
77.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
3
41.9
98.9
acute coronary syndrome
1
72.8
81.8
1
72.8
81.8
response to darapladib
1
77.2
lipoprotein-associated phospholipase A(2) change measurement
1
77.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group VII
VGNC:10021
462744
Macaque
phospholipase A2 group VII
704566
Mouse
MGI:1351327
27226
Rat
RGD:1310734
301265
Dog
phospholipase A2 group VII
VGNC:44632
403848
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group VII
Macaque
phospholipase A2 group VII
Mouse
Rat
Dog
phospholipase A2 group VII
Protein Structure (30 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13093-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
Synthesis, secretion, and deacylation of Ghrelin
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Peptide hormone metabolism
Synthesis, secretion, and deacylation of Ghrelin
Protein-Protein Interactions (112)
1 – 10 of 112
PTPRN
Tbio
Family: Enzyme
Novelty: 0.00076479
p_int: 0.999958475
p_ni: 0.000041525
p_wrong: 1e-9
Score: 0.542
Data Source: BioPlex,STRINGDB
PLA2G1B
Tchem
Family: Enzyme
Novelty: 0.00064842
Score: 0.97
Data Source: STRINGDB
LPCAT2
Tbio
Family: Enzyme
Novelty: 0.02794035
Score: 0.955
Data Source: STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.948
Data Source: STRINGDB
LPCAT1
Tbio
Family: Enzyme
Novelty: 0.01441133
Score: 0.91
Data Source: STRINGDB
APOC3
Tclin
Novelty: 0.0009635
Score: 0.908
Data Source: STRINGDB
LPA
Tbio
Family: Enzyme
Novelty: 0.00054858
Score: 0.905
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.903
Data Source: STRINGDB
PLA2G4A
Tchem
Family: Enzyme
Novelty: 0.00158329
Score: 0.896
Data Source: STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
Score: 0.882
Data Source: STRINGDB
Publication Statistics
PubMed Score  547.10

PubMed score by year
PubTator Score  931.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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