You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PDIA2
Protein disulfide-isomerase A2

Protein Summary
Description
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219406
  • ENSP00000219406
  • ENSG00000185615
  • ENST00000404312
  • ENSP00000384410

Symbol
  • PDIP
  • PDI
  • PDA2
  • PDIP
  • PDIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.82
molecular function
0.67
biological term
0.66
cell type or tissue
0.65
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.11   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.906
Data Source:  STRINGDB
CPB1
Tchem
Family:  Enzyme
Novelty:  0.00108031
Score:  0.798
Data Source:  STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.771
Data Source:  STRINGDB
CANX
Tbio
Novelty:  0.00087002
Score:  0.74
Data Source:  STRINGDB
HYOU1
Tbio
Novelty:  0.00833649
Score:  0.729
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.718
Data Source:  STRINGDB
TXN
Tchem
Novelty:  0.00048949
Score:  0.714
Data Source:  STRINGDB
ARHGDIG
Tbio
Novelty:  0.11734153
Score:  0.687
Data Source:  STRINGDB
ERO1B
Tbio
Novelty:  0.06389159
Score:  0.667
Data Source:  STRINGDB
DNAJC10
Tbio
Novelty:  0.02258366
Score:  0.639
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
10
14
20
99.7
heel bone mineral density
3
8
15
98.9
erythrocyte count
6
8
12
98.1
red blood cell distribution width
7
5
9
97.4
mean corpuscular hemoglobin
3
5
5
97
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
20
99.7
heel bone mineral density
15
98.9
erythrocyte count
12
98.1
red blood cell distribution width
9
97.4
mean corpuscular hemoglobin
5
97
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein disulfide isomerase family A member 2
694964
Mouse
MGI:1916441
69191
Dog
protein disulfide isomerase family A member 2
VGNC:44376
100687738
Cow
protein disulfide isomerase family A member 2
VGNC:32696
504356
Pig
protein disulfide isomerase family A member 2
100738360
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein disulfide isomerase family A member 2
Mouse
Dog
protein disulfide isomerase family A member 2
Cow
protein disulfide isomerase family A member 2
Pig
protein disulfide isomerase family A member 2
Publication Statistics
PubMed Score 61.11
PubMed score by year
PubTator Score 96.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title