Tchem ACACA Acetyl-CoA carboxylase 1

Protein Summary

Description

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13085
• B2RP68
• Q6KEV6
• Q6XDA8
• Q7Z2G8
• Q7Z561
• Q7Z563
• Q7Z564
• Q86WB2
• Q86WB3
• ACC1

Gene Name

• ACACA

Ensembl ID

• ENST00000611803
• ENSP00000479901
• ENSG00000275176
• ENST00000612895
• ENSP00000482269
• ENSG00000278540
• ENST00000613687
• ENSP00000483674
• ENST00000614428
• ENSP00000478547
• ENST00000616317
• ENSP00000483300
• ENST00000617649
• ENSP00000482368
• ENST00000619487
• ENSP00000478577
• ENST00000621312
• ENSP00000480031

Symbol

• ACAC
• ACC1
• ACCA
• ACC
• ACAC
• ACC1
• ACCA
• ACACAD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
protein domain	1
biological process	0.97
molecular function	0.94
transcription factor	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.42   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 581   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 520.42   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 322

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0