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Tbio
TRAF1
TNF receptor-associated factor 1

Protein Classes
Protein Summary
Description
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373887
  • ENSP00000362994
  • ENSG00000056558
  • ENST00000540010
  • ENSP00000443183
  • ENST00000546084
  • ENSP00000438583

Symbol
  • EBI6
  • EBI6
  • MGC:10353
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
kinase perturbation
0.91
virus perturbation
0.88
gene perturbation
0.82
transcription factor
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.36   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.36   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
86.8
lymphocyte count
3
2
3
85.6
monocyte count
1
1
1
44.2
1
1
0
1
20.2
lymphocyte percentage of leukocytes
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
86.8
lymphocyte count
3
85.6
monocyte count
1
44.2
0
1
20.2
lymphocyte percentage of leukocytes
1
9.5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Death Receptor Signalling (R-HSA-73887)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Death Receptor Signalling
Reactome
Regulation of TNFR1 signaling
Reactome
Signal Transduction
Reactome
TNF signaling
Reactome
TNFR1-induced NFkappaB signaling pathway
Name
Explore in Pharos
Explore in Source
Death Receptor Signalling
Regulation of TNFR1 signaling
Signal Transduction
TNF signaling
TNFR1-induced NFkappaB signaling pathway
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (197)
1 – 10 of 197
TRAF2
Tbio
Novelty: 0.00983658
p_int: 1
Score: 0.977
Data Source: BioPlex,STRINGDB
TANK
Tbio
Novelty: 0.01003866
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
p_int: 0.999999917
p_ni: 8.3e-8
Score: 0.723
Data Source: BioPlex,STRINGDB
FBXO28
Tbio
Novelty: 0.10548865
p_int: 0.999999272
p_ni: 7.28e-7
Score: 0.217
Data Source: BioPlex,STRINGDB
BIRC2
Tchem
Novelty: 0.00199701
p_int: 0.99999919
p_ni: 8.1e-7
Score: 0.989
Data Source: BioPlex,STRINGDB
OTUD4
Tbio
Novelty: 0.17121119
p_int: 0.999999098
p_ni: 9.02e-7
Score: 0.217
Data Source: BioPlex,STRINGDB
SNX29
Tdark
Novelty: 0.22265562
p_int: 0.99999853
p_ni: 0.000001386
p_wrong: 8.4e-8
Score: 0.228
Data Source: BioPlex,STRINGDB
TBK1
Tchem
Family: Kinase
Novelty: 0.00194753
p_int: 0.999995929
p_ni: 0.000004071
Score: 0.499
Data Source: BioPlex,STRINGDB
KANSL1
Tbio
Novelty: 0.03032662
p_int: 0.999995617
p_ni: 0.000004383
Score: 0.239
Data Source: BioPlex,STRINGDB
LTBR
Tbio
Novelty: 0.003823
p_int: 0.999982534
p_ni: 0.000017466
Score: 0.517
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  191.36

PubMed score by year
PubTator Score  158.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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