Tbio TRAF1 TNF receptor-associated factor 1

Protein Summary

Description

Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q13077
• B4DJ77
• Q658U1
• Q8NF13

Gene Name

• TRAF1

Ensembl ID

• ENST00000373887
• ENSP00000362994
• ENSG00000056558
• ENST00000540010
• ENSP00000443183
• ENST00000546084
• ENSP00000438583

Symbol

• EBI6
• EBI6
• MGC:10353

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.94
kinase perturbation	0.91
virus perturbation	0.88
gene perturbation	0.82
transcription factor	0.75

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Tnf Receptor-associated Factor 1

DTO Classes

Protein / Signaling / Tnf Receptor-associated Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.81   (req: < 5)

Gene RIFs: 89   (req: <= 3)

Antibodies: 339   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.81   (req: >= 5)

Gene RIFs: 89   (req: > 3)

Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0