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Tbio
NAIP
Baculoviral IAP repeat-containing protein 1

Protein Summary
Description
Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000194097
  • ENSP00000443944
  • ENSG00000249437
  • ENST00000503719
  • ENSP00000424913
  • ENST00000517649
  • ENSP00000428657
  • ENST00000523981
  • ENSP00000428363
  • ENST00000612328
  • ENSP00000484107
  • ENSG00000278613
  • ENST00000620988
  • ENSP00000484731

Symbol
  • BIRC1
  • BIRC1
  • NLRB1
  • psiNAIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.83
gene perturbation
0.81
protein domain
0.73
biological process
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.72   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.72   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
42.3
blood protein measurement
1
1
1
42.3
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
42.3
blood protein measurement
1
42.3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NLR family apoptosis inhibitory protein
705157
Mouse
MGI:1298226
17948
Horse
NLR family apoptosis inhibitory protein
VGNC:20552
100073304
Cow
NLR family apoptosis inhibitory protein
VGNC:31873
539780
Anole lizard
NLR family apoptosis inhibitory protein
100553428
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NLR family apoptosis inhibitory protein
Mouse
Horse
NLR family apoptosis inhibitory protein
Cow
NLR family apoptosis inhibitory protein
Anole lizard
NLR family apoptosis inhibitory protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13075-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (76)
1 – 10 of 76
NLRC4
Tbio
Novelty:  0.0032237
Score:  0.975
Data Source:  STRINGDB
HPCA
Tbio
Novelty:  0.01360155
Score:  0.794
Data Source:  STRINGDB
CIITA
Tbio
Novelty:  0.00245662
Score:  0.765
Data Source:  STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
Score:  0.751
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.742
Data Source:  STRINGDB
SERF1A
Tdark
Novelty:  0.00367382
Score:  0.718
Data Source:  STRINGDB
NOD1
Tchem
Novelty:  0.00241763
Score:  0.707
Data Source:  STRINGDB
NLRP3
Tchem
Novelty:  0.00043957
Score:  0.686
Data Source:  STRINGDB
MEFV
Tbio
Novelty:  0.00074419
Score:  0.682
Data Source:  STRINGDB
SMN1
Tchem
Family:  Epigenetic
Novelty:  0.0008085
Score:  0.676
Data Source:  STRINGDB
Publication Statistics
PubMed Score  244.72

PubMed score by year
PubTator Score  155.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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