Tbio TRDN Triadin

Protein Summary

Description

Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. This gene encodes an integral membrane protein that contains a single transmembrane domain. As similar protein in rabbits plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex in association with the ryanodine receptor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and single nucleotide polymorphisms in this gene may be markers for IgA nephritis. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q13061
• A5D6W5
• F5H2W7
• Q6NSB8

Gene Name

• TRDN

Ensembl ID

• ENST00000334268
• ENSP00000333984
• ENSG00000186439
• ENST00000542443
• ENSP00000437684
• ENST00000628709
• ENSP00000486095

Symbol

• TDN
• CPVT5
• TRISK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
cell type or tissue	0.76
cellular component	0.76
kinase perturbation	0.66
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.83   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 186.83   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (155)

Explore Interacting Targets

1 – 10 of 155

• See Interactions on String-DB

ABCC5

Tchem

Family:  Transporter

Novelty:  0.00566605

p_int:  0.999995049

p_ni:  0.000003107

p_wrong:  0.000001844

Score:  0.192

Data Source:  BioPlex,STRINGDB

TMEM205

Tdark

Novelty:  0.41048198

p_int:  0.99999401

p_ni:  0.000005989

p_wrong:  1e-9

Data Source:  BioPlex

GOLIM4

Tbio

Novelty:  0.01923513

p_int:  0.999924966

p_ni:  0.000075033

p_wrong:  1e-9

Data Source:  BioPlex

JPH1

Tbio

Novelty:  0.00931679

p_int:  0.999633518

p_ni:  0.000366478

p_wrong:  4e-9

Score:  0.832

Data Source:  BioPlex,STRINGDB

ABCB10

Tbio

Family:  Transporter

Novelty:  0.00351852

p_int:  0.999478502

p_ni:  0.000521498

Data Source:  BioPlex

ZFPL1

Tbio

Novelty:  0.1829181

p_int:  0.999135342

p_ni:  0.000861565

p_wrong:  0.000003093

Data Source:  BioPlex

TMEM223

Tdark

Novelty:  0.89146194

p_int:  0.998982064

p_ni:  0.00101689

p_wrong:  0.000001046

Data Source:  BioPlex

TMEM9B

Tdark

Novelty:  0.56628366

p_int:  0.998422985

p_ni:  0.000008586

p_wrong:  0.001568429

Data Source:  BioPlex

EMC3

Tbio

Novelty:  0.01113829

p_int:  0.996524045

p_ni:  0.003475955

Score:  0.666

Data Source:  BioPlex,STRINGDB

VTI1B

Tbio

Novelty:  0.00955467

p_int:  0.995568602

p_ni:  0.004431384

p_wrong:  1.4e-8

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (6)

KEGG (2)

Cardiac conduction (R-HSA-5576891)

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Find Similar Targets

Items per page:

5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Ion homeostasis	52 targets	R-HSA-5578775
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Stimuli-sensing channels	102 targets	R-HSA-2672351

Name	Explore in Pharos	Explore in Source
Cardiac conduction	137 targets	R-HSA-5576891
Ion channel transport	179 targets	R-HSA-983712
Ion homeostasis	52 targets	R-HSA-5578775
Muscle contraction	202 targets	R-HSA-397014
Stimuli-sensing channels	102 targets	R-HSA-2672351

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (3)

Components (9)

Processes (16)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
ion channel binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
protein binding, bridging	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
signaling receptor binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	1	1	0	6.8	50.6
electrocardiography	EFO_0004327	1	1	2		39.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intraocular pressure measurement	EFO_0004695	0	6.8	50.6
electrocardiography	EFO_0004327	2		39.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
electrocardiography
intraocular pressure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
muscle phenotype

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	triadin	VGNC:52147	744745
Macaque	triadin		713373
Mouse	triadin	MGI:1924007	76757
Dog	triadin	VGNC:47791	403776
Zebrafish	triadin	ZDB-GENE-041014-193	100038781

Species	Name	OMA	EggNOG	Inparanoid
Chimp	triadin
Macaque	triadin
Mouse	triadin
Dog	triadin
Zebrafish	triadin

Publication Statistics

PubMed Score 186.83

PubMed score by year

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PubTator Score 25.06

PubTator score by year

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Related Publications

Text Mined References (25)

GeneRif Annotations (13)

Items per page:

10

0 of 0

PMID	Year	Title