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Tbio
FLII
Protein flightless-1 homolog

Protein Summary
Description
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327031
  • ENSP00000324573
  • ENSG00000177731
  • ENST00000545457
  • ENSP00000438536
  • ENST00000579294
  • ENSP00000463534
  • ENST00000638207
  • ENSP00000491480
  • ENSG00000284571
  • ENST00000638404
  • ENSP00000492392
  • ENST00000638812
  • ENSP00000491660

Symbol
  • FLIL
  • FLI
  • FLIL
  • Fli1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
disease perturbation
0.97
protein domain
0.92
gene perturbation
0.78
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 519.16   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 519.16   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.999967533
p_ni:  0.000032467
Score:  0.419
Data Source:  BioPlex,STRINGDB
LRRFIP1
Tbio
Novelty:  0.02584638
p_int:  0.999915339
p_ni:  0.000084661
Score:  0.979
Data Source:  BioPlex,STRINGDB
TMOD1
Tbio
Novelty:  0.01142927
p_int:  0.999904543
p_ni:  0.000095457
Score:  0.76
Data Source:  BioPlex,STRINGDB
TMOD4
Tbio
Novelty:  0.00932697
p_int:  0.996965429
p_ni:  0.003034571
Score:  0.571
Data Source:  BioPlex,STRINGDB
NAT9
Tbio
Family:  Enzyme
Novelty:  0.07036821
p_int:  0.805511943
p_ni:  0.194488057
Score:  0.272
Data Source:  BioPlex,STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.805138712
p_ni:  0.194861288
Data Source:  BioPlex
SSSCA1
Tdark
Novelty:  0.53523038
p_int:  0.789566733
p_ni:  0.210433267
Data Source:  BioPlex
LRRFIP2
Tbio
Novelty:  0.15492934
Score:  0.878
Data Source:  STRINGDB
EWSR1
Tbio
Novelty:  0.00068411
Score:  0.836
Data Source:  STRINGDB
LLGL1
Tbio
Novelty:  0.01591552
Score:  0.771
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
72.9
systolic blood pressure
1
1
1
72.9
BMI-adjusted waist-hip ratio
1
3
3
72.3
BMI-adjusted waist-hip ratio
1
3
3
72.3
red blood cell density measurement
1
1
1
67.9
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
72.9
systolic blood pressure
1
72.9
BMI-adjusted waist-hip ratio
3
72.3
BMI-adjusted waist-hip ratio
3
72.3
red blood cell density measurement
1
67.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FLII, actin remodeling protein
VGNC:10348
454486
Macaque
FLII, actin remodeling protein
700471
Mouse
MGI:1342286
14248
Rat
RGD:1307590
287375
Dog
FLII, actin remodeling protein
VGNC:40899
479521
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FLII, actin remodeling protein
Macaque
FLII, actin remodeling protein
Mouse
Rat
Dog
FLII, actin remodeling protein
Publication Statistics
PubMed Score 519.16
PubMed score by year
PubTator Score 134.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title