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Tchem
STK4
Serine/threonine-protein kinase 4

Protein Summary
Description
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372801
  • ENSP00000361887
  • ENSG00000101109
  • ENST00000372806
  • ENSP00000361892

Symbol
  • KRS2
  • MST1
  • KRS2
  • MST1
  • YSK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
drug perturbation
0.99
phosphatase
0.95
biological process
0.93
kinase
0.9


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.22   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 388   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.22   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 388   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
89.8
self reported educational attainment
1
1
1
31.3
platelet count
1
1
1
20
feeling "fed-up" measurement
1
1
0
5.7
18.5
mathematical ability
1
1
1
16.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
89.8
self reported educational attainment
1
31.3
platelet count
1
20
feeling "fed-up" measurement
0
5.7
18.5
mathematical ability
1
16.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 4
VGNC:14480
458275
Macaque
serine/threonine kinase 4
717730
Mouse
MGI:1929004
58231
Rat
RGD:1312035
311622
Dog
serine/threonine kinase 4
VGNC:46922
477240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 4
Macaque
serine/threonine kinase 4
Mouse
Rat
Dog
serine/threonine kinase 4
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13043-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (138)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (46)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Genetic Interaction (IGI)
MGI
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (79)
1 – 10 of 79
RASSF2
Tbio
Novelty: 0.031565
p_int: 0.999999648
p_ni: 3.52e-7
Score: 0.848
Data Source: BioPlex,STRINGDB
RASSF1
Tbio
Novelty: 0.00137149
p_int: 0.999999112
p_ni: 8.88e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
SAV1
Tbio
Novelty: 0.00962335
p_int: 0.999988108
p_ni: 0.000011892
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
RASSF6
Tbio
Novelty: 0.04940382
p_int: 0.999982432
p_ni: 0.000017568
Score: 0.827
Data Source: BioPlex,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.997765624
p_ni: 0.002234376
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.994742264
p_ni: 0.005257736
Score: 0.235
Data Source: BioPlex,STRINGDB
ZNF554
Tdark
Family: TF
Novelty: 1.57478216
p_int: 0.994363622
p_ni: 0.005636378
Data Source: BioPlex
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.985458036
p_ni: 0.014541964
Data Source: BioPlex
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.971144446
p_ni: 0.028855554
Data Source: BioPlex
ZNF133
Tbio
Family: TF
Novelty: 0.20117958
p_int: 0.851617445
p_ni: 0.148382555
Score: 0.542
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.22

PubMed score by year
PubTator Score  17.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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