Tbio CDC16 Cell division cycle protein 16 homolog

Protein Summary

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q13042
• A2A365
• Q5T8C8
• Q7Z651
• Q96AE6
• Q9Y564

Gene Name

• CDC16

Ensembl ID

• ENST00000252457
• ENSP00000252457
• ENSG00000130177
• ENST00000356221
• ENSP00000348554
• ENST00000360383
• ENSP00000353549
• ENST00000375308
• ENSP00000364457
• ENST00000375310
• ENSP00000364459

Symbol

• ANAPC6
• APC6
• CUT9
• ANAPC6
• CDC16Hs

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
biological process	0.94
disease perturbation	0.93
cellular component	0.91
kinase perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.23   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 382   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.23   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0