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Tbio
PRDM2
PR domain zinc finger protein 2

Protein Summary
Description
S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene. This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSe ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235372
  • ENSP00000235372
  • ENSG00000116731
  • ENST00000311066
  • ENSP00000312352
  • ENST00000343137
  • ENSP00000341621
  • ENST00000376048
  • ENSP00000365216
  • ENST00000413440
  • ENSP00000411103

Symbol
  • KMT8
  • RIZ
  • RIZ
  • KMT8
  • RIZ1
  • RIZ2
  • KMT8A
  • MTB-ZF
  • HUMHOXY1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
ligand (protein) perturbation
0.83
molecular function
0.81
histone modification site profile
0.77
transcription factor
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.61   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.61   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
CTBP1
Tbio
Novelty:  0.00243818
p_int:  1
Score:  0.393
Data Source:  BioPlex,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.793
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.753
Data Source:  STRINGDB
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
Score:  0.75
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.74
Data Source:  STRINGDB
PRDM8
Tbio
Family:  TF; Epigenetic
Novelty:  0.08003201
Score:  0.706
Data Source:  STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.691
Data Source:  STRINGDB
KMT5B
Tchem
Family:  Epigenetic
Novelty:  0.04892469
Score:  0.69
Data Source:  STRINGDB
KMT2C
Tbio
Family:  Epigenetic
Novelty:  0.00689437
Score:  0.674
Data Source:  STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
Score:  0.658
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
3.1
57.3
puberty onset measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
3.1
57.3
puberty onset measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 2
VGNC:8095
469125
Macaque
PR/SET domain 2
716295
Mouse
MGI:107628
110593
Rat
RGD:1594531
313678
Dog
PR/SET domain 2
VGNC:52232
100688431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 2
Macaque
PR/SET domain 2
Mouse
Rat
Dog
PR/SET domain 2
Publication Statistics
PubMed Score 160.61
PubMed score by year
PubTator Score 116.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title