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Tbio
PLA2R1
Secretory phospholipase A2 receptor

Protein Summary
Description
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in proinflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283243
  • ENSP00000283243
  • ENSG00000153246
  • ENST00000392771
  • ENSP00000376524

Symbol
  • CLEC13C
  • PLA2R
  • PLA2-R
  • PLA2IR
  • CLEC13C
  • PLA2G1R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
protein domain
0.85
virus perturbation
0.79
histone modification site profile
0.75
biological process
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.01   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 435.01   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
2.3
97.4
platelet crit
2
7
7
95.1
platelet count
3
6
6
89.8
urokinase plasminogen activator surface receptor measurement
1
1
1
79
neutrophil count
2
2
2
60.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.3
97.4
platelet crit
7
95.1
platelet count
6
89.8
urokinase plasminogen activator surface receptor measurement
1
79
neutrophil count
2
60.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 receptor 1
VGNC:2756
739140
Mouse
MGI:102468
18779
Rat
RGD:1309777
295631
Dog
phospholipase A2 receptor 1
VGNC:44633
488367
Horse
phospholipase A2 receptor 1
VGNC:21520
100060317
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 receptor 1
Mouse
Rat
Dog
phospholipase A2 receptor 1
Horse
phospholipase A2 receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13018-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Protein-Protein Interactions (35)
1 – 10 of 35
THSD7A
Tbio
Novelty:  0.01515873
Score:  0.876
Data Source:  STRINGDB
PLA2G2A
Tchem
Family:  Enzyme
Novelty:  0.00105131
Score:  0.869
Data Source:  STRINGDB
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
Score:  0.866
Data Source:  STRINGDB
PLA2G1B
Tchem
Family:  Enzyme
Novelty:  0.00064842
Score:  0.86
Data Source:  STRINGDB
MRC1
Tbio
Novelty:  0.00104675
Score:  0.819
Data Source:  STRINGDB
MRC2
Tbio
Novelty:  0.01100289
Score:  0.818
Data Source:  STRINGDB
PDHX
Tbio
Family:  Enzyme
Novelty:  0.00946631
Score:  0.748
Data Source:  STRINGDB
PLA2G2D
Tchem
Family:  Enzyme
Novelty:  0.01212618
Score:  0.681
Data Source:  STRINGDB
HLA-DQA2
Tbio
Novelty:  0.00431613
Score:  0.673
Data Source:  STRINGDB
PLA2G5
Tchem
Family:  Enzyme
Novelty:  0.0251629
Score:  0.645
Data Source:  STRINGDB
Publication Statistics
PubMed Score  435.01

PubMed score by year
PubTator Score  213.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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