Tbio ARHGAP5 Rho GTPase-activating protein 5

Protein Summary

Description

GTPase-activating protein for Rho family members (PubMed:8537347). Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13017
• A1L375
• A1L376
• A8KAA1
• D3DS89
• D3DS90
• Q05BE8
• Q05BU8
• Q59ER0
• Q6DHZ3

Gene Name

• ARHGAP5

Ensembl ID

• ENST00000345122
• ENSP00000371897
• ENSG00000100852
• ENST00000396582
• ENSP00000379827
• ENST00000433497
• ENSP00000407395
• ENST00000539826
• ENSP00000441692
• ENST00000556611
• ENSP00000452222

Symbol

• RHOGAP5
• GFI2
• p190-B
• RhoGAP5
• p190BRhoGAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
microRNA	0.84
transcription factor perturbation	0.74
protein domain	0.73
histone modification site profile	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.62   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.62   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0