TIAM1
T-lymphoma invasion and metastasis-inducing protein 1
Protein Summary
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additi ...more
- ENST00000286827
- ENSP00000286827
- ENSG00000156299
- ENST00000541036
- ENSP00000441570
- TIAM-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.86 | ||
protein domain | 0.85 | ||
hub protein | 0.79 | ||
microRNA | 0.78 | ||
PubMedID | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.52 (req: < 5)
Gene RIFs: 107 (req: <= 3)
Antibodies: 192 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 262.52 (req: >= 5)
Gene RIFs: 107 (req: > 3)
Antibodies: 192 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (168)
ABTB2
Novelty: 0.45729157
p_int: 0.979304102
p_ni: 0.001386283
p_wrong: 0.019309614
Data Source: BioPlex
Nearest Tclin Targets (7)
Upstream (5)
Downstream (2)
1 – 5 of 5
Pathways (48)
Reactome (19)
KEGG (7)
PathwayCommons (10)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated NTRK2 signals through CDK5 | ||||
Reactome | Axon guidance | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated NTRK2 signals through CDK5 | ||||
Axon guidance | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
Developmental Biology | ||||
Viral Interactions (0)
Gene Ontology Terms (51)
Functions (7)
Components (14)
Processes (30)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 2 | 17.8 | |||||
smoking status measurement | 1 | 1 | 1 | 0.7 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 2 | 17.8 | |||||
smoking status measurement | 1 | 0.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | T cell lymphoma invasion and metastasis 1 | VGNC:1118 | 473949 | |||||
Macaque | T-cell lymphoma invasion and metastasis 1 | 702288 | ||||||
Mouse | MGI:103306 | 21844 | ||||||
Rat | RGD:1307455 | 304109 | ||||||
Dog | T-cell lymphoma invasion and metastasis 1 | 487731 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | T cell lymphoma invasion and metastasis 1 | |||||
Macaque | T-cell lymphoma invasion and metastasis 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | T-cell lymphoma invasion and metastasis 1 | |||||
Publication Statistics
PubMed Score 262.52
PubMed score by year
PubTator Score 166.80
PubTator score by year
Related Publications
Text Mined References (144)
GeneRif Annotations (107)
Items per page:
0 of 0
PMID | Year | Title |
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