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Tbio
TIAM1
T-lymphoma invasion and metastasis-inducing protein 1

Protein Summary
Description
Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration. This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286827
  • ENSP00000286827
  • ENSG00000156299
  • ENST00000541036
  • ENSP00000441570

Symbol
  • TIAM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
protein domain
0.85
hub protein
0.79
microRNA
0.78
PubMedID
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.06   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.06   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2
46.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
46.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T cell lymphoma invasion and metastasis 1
VGNC:1118
473949
Macaque
T-cell lymphoma invasion and metastasis 1
702288
Mouse
MGI:103306
21844
Rat
RGD:1307455
304109
Dog
T-cell lymphoma invasion and metastasis 1
487731
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T cell lymphoma invasion and metastasis 1
Macaque
T-cell lymphoma invasion and metastasis 1
Mouse
Rat
Dog
T-cell lymphoma invasion and metastasis 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13009-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (48)
Activated NTRK2 signals through CDK5 (R-HSA-9032845)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through CDK5
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through CDK5
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
Developmental Biology
Gene Ontology Terms (51)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (168)
1 – 10 of 168
ABTB2
Tdark
Novelty: 0.45729157
p_int: 0.979304102
p_ni: 0.001386283
p_wrong: 0.019309614
Data Source: BioPlex
EPHB2
Tchem
Family: Kinase
Novelty: 0.00211785
Score: 0.991
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.987
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.985
Data Source: Reactome,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.98
Data Source: STRINGDB
NME1
Tbio
Family: Kinase
Novelty: 0.00103216
Score: 0.977
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.973
Data Source: STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.973
Data Source: Reactome,STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.972
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  255.06

PubMed score by year
PubTator Score  166.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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