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Tbio
IL24
Interleukin-24

Protein Summary
Description
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294984
  • ENSP00000294984
  • ENSG00000162892
  • ENST00000367093
  • ENSP00000356060
  • ENST00000391929
  • ENSP00000375795
  • ENST00000611909
  • ENSP00000484900

Symbol
  • MDA7
  • ST16
  • C49A
  • FISP
  • MDA7
  • MOB5
  • ST16
  • IL10B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
gene perturbation
0.9
biological term
0.85
protein domain
0.73
PubMedID
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.22   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 587.22   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
83.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 24
VGNC:1270
457683
Macaque
interleukin 24
694541
Mouse
MGI:2135548
93672
Rat
RGD:621484
170819
Dog
interleukin 24
VGNC:41974
609213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 24
Macaque
interleukin 24
Mouse
Rat
Dog
interleukin 24
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13007-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (161)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (94)
1 – 10 of 94
IL20RA
Tbio
Novelty:  0.02416816
Score:  0.986
Data Source:  Reactome,STRINGDB
IL20RB
Tbio
Novelty:  0.01747619
Score:  0.975
Data Source:  Reactome,STRINGDB
IL22RA1
Tbio
Novelty:  0.01107638
Score:  0.971
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.945
Data Source:  Reactome,STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.936
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.926
Data Source:  Reactome,STRINGDB
IL10RB
Tbio
Novelty:  0.00880915
Score:  0.849
Data Source:  STRINGDB
IL10RA
Tbio
Novelty:  0.00506068
Score:  0.801
Data Source:  STRINGDB
IL22RA2
Tbio
Novelty:  0.03455127
Score:  0.78
Data Source:  STRINGDB
IL26
Tbio
Novelty:  0.01233835
Score:  0.738
Data Source:  STRINGDB
Publication Statistics
PubMed Score  587.22

PubMed score by year
PubTator Score  260.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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