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Tclin
GRIK3
Glutamate receptor ionotropic, kainate 3

Protein Summary
Description
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373091
  • ENSP00000362183
  • ENSG00000163873
  • ENST00000373093
  • ENSP00000362185

Symbol
  • GLUR7
  • EAA5
  • GLR7
  • GLUR7
  • GluK3
  • GluR7a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.73
microRNA
0.72
PubMedID
0.64
cell type or tissue
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 3
VGNC:8048
469281
Macaque
glutamate ionotropic receptor kainate type subunit 3
713545
Mouse
MGI:95816
14807
Rat
RGD:71027
298521
Dog
glutamate ionotropic receptor kainate type subunit 3
VGNC:41488
608269
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 3
Macaque
glutamate ionotropic receptor kainate type subunit 3
Mouse
Rat
Dog
glutamate ionotropic receptor kainate type subunit 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13003-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Ionotropic activity of kainate receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of kainate receptors upon glutamate binding
Ionotropic activity of kainate receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (75)
1 – 10 of 75
GRIK5
Tclin
Family: IC
Novelty: 0.00346213
Score: 0.985
Data Source: Reactome,STRINGDB
GRIK4
Tclin
Family: IC
Novelty: 0.0033299
Score: 0.975
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.945
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.941
Data Source: Reactome,STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.932
Data Source: STRINGDB
GRIK2
Tclin
Family: IC
Novelty: 0.00293615
Score: 0.931
Data Source: Reactome,STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.913
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.91
Data Source: STRINGDB
PLCB3
Tbio
Family: Enzyme
Novelty: 0.01388454
Score: 0.909
Data Source: Reactome,STRINGDB
PLCB1
Tbio
Family: Enzyme
Novelty: 0.00269771
Score: 0.909
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  47.39

PubMed score by year
PubTator Score  40.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer