Tclin GRIK2 Glutamate receptor ionotropic, kainate 2

Protein Summary

Description

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity). Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13002
• A6NMY9
• B5MCV0
• D7RWZ3
• D7RWZ4
• D7RWZ5
• D7RWZ6
• D7RWZ7
• Q8WWS1
• Q96KS6
• Q96KS7
• Q96KS8
• GluK2

Gene Name

• GRIK2

Ensembl ID

• ENST00000369138
• ENSP00000358134
• ENSG00000164418
• ENST00000413795
• ENSP00000405596
• ENST00000421544
• ENSP00000397026

Symbol

• GLUR6
• EAA4
• GLR6
• MRT6
• GLUK6
• GLUR6
• GluK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
molecular function	0.98
biological process	0.87
drug	0.85
disease perturbation	0.74

Protein Classes

DTO Classes

Protein / Ion Channel / Glutamate-gated Ion Channel (Gic) Family Of Neurotransmitter Receptors / Grik2 Subfamily / Glutamate Receptor Ionotropic, Kainate 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.87   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 300   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.87   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 81

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3