You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GRIK2
Glutamate receptor ionotropic, kainate 2

Protein Summary
Description
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity). Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369138
  • ENSP00000358134
  • ENSG00000164418
  • ENST00000413795
  • ENSP00000405596
  • ENST00000421544
  • ENSP00000397026

Symbol
  • GLUR6
  • EAA4
  • GLR6
  • MRT6
  • GLUK6
  • GLUR6
  • GluK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.98
biological process
0.87
drug
0.85
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.05   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.05   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 81
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
77.1
heart rate response to recovery post exercise
1
1
1
22.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
77.1
heart rate response to recovery post exercise
1
22.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 2
VGNC:8166
462899
Mouse
MGI:95815
14806
Rat
RGD:2733
54257
Dog
glutamate ionotropic receptor kainate type subunit 2
VGNC:41487
481938
Horse
glutamate ionotropic receptor kainate type subunit 2
VGNC:18586
100066235
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 2
Mouse
Rat
Dog
glutamate ionotropic receptor kainate type subunit 2
Horse
glutamate ionotropic receptor kainate type subunit 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13002-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of Na-permeable kainate receptors
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Ionotropic activity of kainate receptors
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of Na-permeable kainate receptors
Activation of kainate receptors upon glutamate binding
Ionotropic activity of kainate receptors
Neuronal System
Gene Ontology Terms (38)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (143)
1 – 10 of 143
DLG4
Tchem
Novelty: 0.00057285
Score: 0.989
Data Source: Reactome,STRINGDB
GRIK5
Tclin
Family: IC
Novelty: 0.00346213
Score: 0.988
Data Source: Reactome,STRINGDB
GRIK4
Tclin
Family: IC
Novelty: 0.0033299
Score: 0.98
Data Source: Reactome,STRINGDB
DLG1
Tbio
Novelty: 0.0050926
Score: 0.978
Data Source: STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.968
Data Source: Reactome,STRINGDB
GRIK3
Tclin
Family: IC
Novelty: 0.01816701
Score: 0.931
Data Source: Reactome,STRINGDB
GRIK1
Tclin
Family: IC
Novelty: 0.00283685
Score: 0.931
Data Source: Reactome,STRINGDB
NCALD
Tbio
Novelty: 0.03665351
Score: 0.907
Data Source: STRINGDB
KLHL24
Tbio
Novelty: 0.04032749
Score: 0.867
Data Source: STRINGDB
NETO2
Tbio
Novelty: 0.0414181
Score: 0.822
Data Source: STRINGDB
Publication Statistics
PubMed Score  352.05

PubMed score by year
PubTator Score  184.36

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: