Tbio TSPAN31 Tetraspanin-31

Protein Summary

Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q12999
• O00577
• Q53X76
• Tspan-31

Gene Name

• TSPAN31

Ensembl ID

• ENST00000257910
• ENSP00000257910
• ENSG00000135452

Symbol

• SAS
• SAS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
disease perturbation	0.95
virus perturbation	0.92
kinase perturbation	0.88
gene perturbation	0.76

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.6   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.6   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (10)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	4	4	0	1.1	94
urate measurement	EFO_0004531	1	1	1		71.9
high density lipoprotein cholesterol measurement	EFO_0004612	1	1	1		59.9
mathematical ability	EFO_0004875	2	2	2		57.7
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		52.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	0	1.1	94
urate measurement	EFO_0004531	1		71.9
high density lipoprotein cholesterol measurement	EFO_0004612	1		59.9
mathematical ability	EFO_0004875	2		57.7
apolipoprotein A 1 measurement	EFO_0004614	1		52.7

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 31	VGNC:13484	746219
Macaque	tetraspanin 31		715700
Mouse	tetraspanin 31	MGI:1914375	67125
Rat	tetraspanin 31	RGD:1309876	362890
Dog	tetraspanin 31	VGNC:47920	403676

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tetraspanin 31
Macaque	tetraspanin 31
Mouse	tetraspanin 31
Rat	tetraspanin 31
Dog	tetraspanin 31

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q12999-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)

Components (2)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
integral component of plasma membrane	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
membrane	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (118)

Explore Interacting Targets

1 – 10 of 118

• See Interactions on String-DB

BCL2L13

Tbio

Novelty:  0.01844825

p_int:  0.999999999

Data Source:  BioPlex

NRM

Tbio

Novelty:  0.02136368

p_int:  0.999988868

p_ni:  0.000008754

p_wrong:  0.000002378

Data Source:  BioPlex

ALG14

Tbio

Family:  Enzyme

Novelty:  0.09271278

p_int:  0.999959376

p_ni:  0.000036202

p_wrong:  0.000004422

Data Source:  BioPlex

RETREG2

Tdark

Novelty:  0.18851807

p_int:  0.999905429

p_ni:  0.000083037

p_wrong:  0.000011534

Data Source:  BioPlex

ATP1B2

Tclin

Family:  Transporter

Novelty:  0.02641193

p_int:  0.999866125

p_ni:  0.000010171

p_wrong:  0.000123704

Data Source:  BioPlex

FXYD6

Tbio

Family:  IC

Novelty:  0.0503209

p_int:  0.999511943

p_ni:  0.000408032

p_wrong:  0.000080025

Data Source:  BioPlex

ZDHHC7

Tbio

Family:  Enzyme

Novelty:  0.07453193

p_int:  0.996900902

p_ni:  1.01e-7

p_wrong:  0.003098997

Data Source:  BioPlex

LAPTM4B

Tbio

Novelty:  0.01162533

p_int:  0.996756462

p_ni:  0.000366815

p_wrong:  0.002876723

Data Source:  BioPlex

MT-ATP8

Tbio

Family:  Enzyme

Novelty:  0.00249065

p_int:  0.996371988

p_ni:  0.003447198

p_wrong:  0.000180814

Data Source:  BioPlex

SLC35F2

Tbio

Family:  Transporter

Novelty:  0.08323418

p_int:  0.992014913

p_ni:  0.007555804

p_wrong:  0.000429284

Data Source:  BioPlex

Publication Statistics

PubMed Score  6.60

PubMed score by year

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PubTator Score  77

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Glycoprotein
Membrane
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
BMI-adjusted waist circumference
body fat distribution
heel bone mineral density
hematocrit
high density lipoprotein cholesterol measurement
mathematical ability
mean platelet volume
multiple sclerosis
urate measurement