Protein Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]
- ENST00000257910
- ENSP00000257910
- ENSG00000135452
- SAS
- SAS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.96 | ||
disease perturbation | 0.95 | ||
virus perturbation | 0.92 | ||
kinase perturbation | 0.88 | ||
gene perturbation | 0.76 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.77 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 120 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.77 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 120 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Gene Ontology Terms (4)
Components (2)
Processes (2)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (118)
1 – 10 of 118
BCL2L13
Novelty: 0.02325978
p_int: 0.999999999
Data Source: BioPlex
NRM
Novelty: 0.04643449
p_int: 0.999988868
p_ni: 0.000008754
p_wrong: 0.000002378
Data Source: BioPlex
ALG14
Family: Enzyme
Novelty: 0.1802962
p_int: 0.999959376
p_ni: 0.000036202
p_wrong: 0.000004422
Data Source: BioPlex
RETREG2
Novelty: 0.375
p_int: 0.999905429
p_ni: 0.000083037
p_wrong: 0.000011534
Data Source: BioPlex
ATP1B2
Family: Transporter
Novelty: 0.03783397
p_int: 0.999866125
p_ni: 0.000010171
p_wrong: 0.000123704
Data Source: BioPlex
FXYD6
Family: IC
Novelty: 0.05831997
p_int: 0.999511943
p_ni: 0.000408032
p_wrong: 0.000080025
Data Source: BioPlex
ZDHHC7
Family: Enzyme
Novelty: 0.08484321
p_int: 0.996900902
p_ni: 1.01e-7
p_wrong: 0.003098997
Data Source: BioPlex
LAPTM4B
Novelty: 0.01087209
p_int: 0.996756462
p_ni: 0.000366815
p_wrong: 0.002876723
Data Source: BioPlex
MT-ATP8
Family: Enzyme
Novelty: 0.00394859
p_int: 0.996371988
p_ni: 0.003447198
p_wrong: 0.000180814
Data Source: BioPlex
SLC35F2
Family: Transporter
Novelty: 0.14326322
p_int: 0.992014913
p_ni: 0.007555804
p_wrong: 0.000429284
Data Source: BioPlex
Publication Statistics
PubMed Score 4.77
PubMed score by year
PubTator Score 77
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MVCGGFACSKNALCALNVVYMLVSLLLIGVAAWGKGLGLVSSIHIIGGVIAVGVFLLLIAVAGLVGAVNH
1-70
HQVLLFFYMIILGLVFIFQFVISCSCLAINRSKQTDVINASWWVMSNKTRDELERSFDCCGLFNLTTLYQ
70-140
QDYDFCTAICKSQSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL
140-210
MVCGGFACSKNALCALNVVYMLVSLLLIGVAAWGKGLGLVSSIHIIGGVIAVGVFLLLIAVAGLVGAVNHHQVLLFFYMIILGLVFIFQFVISCSCLAINRSKQTDVINASWWVMSNKTRDELERSFDCCGLFNLTTLYQQDYDFCTAICKSQSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL
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