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Tbio
CSTF3
Cleavage stimulation factor subunit 3

Protein Summary
Description
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323959
  • ENSP00000315791
  • ENSG00000176102
  • ENST00000431742
  • ENSP00000393064
  • ENST00000438862
  • ENSP00000388711

Symbol
  • CSTF-77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.97
kinase perturbation
0.95
virus perturbation
0.94
transcription factor binding site profile
0.91
interacting protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
55.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
55.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 3
VGNC:10181
451108
Macaque
cleavage stimulation factor subunit 3
694040
Mouse
MGI:1351825
228410
Rat
RGD:1305901
362178
Dog
cleavage stimulation factor subunit 3
VGNC:39684
475948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cleavage stimulation factor subunit 3
Macaque
cleavage stimulation factor subunit 3
Mouse
Rat
Dog
cleavage stimulation factor subunit 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12996-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (293)
1 – 10 of 293
CSTF2T
Tbio
Novelty: 0.11811814
p_int: 0.999999998
p_ni: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BMP1
Tchem
Novelty: 0.00299518
p_int: 0.999041059
p_ni: 0.000958941
Data Source: BioPlex
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.997334306
p_ni: 0.002665668
p_wrong: 2.7e-8
Data Source: BioPlex
MFAP4
Tbio
Novelty: 0.02023782
p_int: 0.995119341
p_ni: 0.004880658
Data Source: BioPlex
CCNL2
Tbio
Novelty: 0.03667817
p_int: 0.887348772
p_ni: 0.112626981
p_wrong: 0.000024247
Score: 0.24
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.8850303
p_ni: 0.114969313
p_wrong: 3.88e-7
Score: 0.193
Data Source: BioPlex,STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.854371854
p_ni: 0.145627933
p_wrong: 2.13e-7
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.845126593
p_ni: 0.154873076
p_wrong: 3.31e-7
Score: 0.919
Data Source: BioPlex,STRINGDB
C1QL4
Tdark
Novelty: 0.37071722
p_int: 0.771801372
p_ni: 0.228197928
p_wrong: 7e-7
Score: 0.186
Data Source: BioPlex,STRINGDB
RABIF
Tbio
Novelty: 0.22512579
p_int: 0.764906685
p_ni: 0.235069876
p_wrong: 0.000023439
Data Source: BioPlex
Publication Statistics
PubMed Score  16.22

PubMed score by year
PubTator Score  10.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer