CSTF3
Cleavage stimulation factor subunit 3
Protein Summary
One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. The protein encoded by this gene is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000323959
- ENSP00000315791
- ENSG00000176102
- ENST00000431742
- ENSP00000393064
- ENST00000438862
- ENSP00000388711
- CSTF-77
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.97 | ||
kinase perturbation | 0.95 | ||
virus perturbation | 0.94 | ||
transcription factor binding site profile | 0.91 | ||
interacting protein | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.92 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 201 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.92 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 201 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0