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Tbio
BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Protein Summary
Description
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368636
  • ENSP00000357625
  • ENSG00000176171

Symbol
  • NIP3
  • NIP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
kinase perturbation
0.97
biological process
0.96
PubMedID
0.94
drug perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 524.47   (req: < 5)
Gene RIFs: 111   (req: <= 3)
Antibodies: 504   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 524.47   (req: >= 5)
Gene RIFs: 111   (req: > 3)
Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
83.3
self reported educational attainment
3
2
3
78.4
C-reactive protein measurement
2
1
2
62.1
systolic blood pressure
1
1
1
59.8
intelligence
3
3
2
5.6
44.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
83.3
self reported educational attainment
3
78.4
C-reactive protein measurement
2
62.1
systolic blood pressure
1
59.8
intelligence
2
5.6
44.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 3
VGNC:13046
450831
Macaque
BCL2 interacting protein 3
100426120
Mouse
MGI:109326
12176
Rat
RGD:620800
84480
Dog
BCL2 interacting protein 3
VGNC:38493
607408
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 3
Macaque
BCL2 interacting protein 3
Mouse
Rat
Dog
BCL2 interacting protein 3
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12983-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (33)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Legionellosis
KEGG
Autophagy - animal
KEGG
FoxO signaling pathway
KEGG
Mitophagy - animal
Name
Explore in Pharos
Explore in Source
Legionellosis
Autophagy - animal
FoxO signaling pathway
Mitophagy - animal
Protein-Protein Interactions (157)
1 – 10 of 157
BNIP3L
Tbio
Novelty:  0.00579795
p_int:  0.999999999
p_ni:  1e-9
Score:  0.425
Data Source:  BioPlex,STRINGDB
PPTC7
Tdark
Family:  Enzyme
Novelty:  0.36770849
p_int:  0.99984567
p_ni:  0.000152439
p_wrong:  0.000001891
Score:  0.188
Data Source:  BioPlex,STRINGDB
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.974823502
p_ni:  0.025162983
p_wrong:  0.000013515
Score:  0.281
Data Source:  BioPlex,STRINGDB
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.960476033
p_ni:  0.00862772
p_wrong:  0.030896247
Data Source:  BioPlex
ENPEP
Tchem
Family:  Enzyme
Novelty:  0.00112857
p_int:  0.947875827
p_ni:  0.015232335
p_wrong:  0.036891838
Score:  0.37
Data Source:  BioPlex,STRINGDB
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.866262889
p_ni:  0.13037593
p_wrong:  0.003361181
Data Source:  BioPlex
PPP4R3B
Tbio
Family:  Enzyme
Novelty:  0.0185504
p_int:  0.812072593
p_ni:  0.187927406
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
RHEB
Tbio
Family:  Enzyme
Novelty:  0.00313935
Score:  0.986
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.961
Data Source:  STRINGDB
GABARAPL1
Tbio
Novelty:  0.00212657
Score:  0.943
Data Source:  STRINGDB
Publication Statistics
PubMed Score  524.47

PubMed score by year
PubTator Score  218.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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