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Tbio
BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Protein Summary
Description
Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000415213
  • ENSP00000412767
  • ENSG00000140299
  • ENST00000607373
  • ENSP00000475320

Symbol
  • NIP2
  • NIP2
  • BNIP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
disease perturbation
0.96
transcription factor perturbation
0.91
transcription factor binding site profile
0.88
microRNA
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.56   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.56   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
0.3
lymphocyte percentage of leukocytes
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
0.3
lymphocyte percentage of leukocytes
1
0.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 2
VGNC:11829
453484
Macaque
BCL2 interacting protein 2
703234
Mouse
MGI:109327
12175
Rat
RGD:1308944
300811
Dog
BCL2 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:1083]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 interacting protein 2
Macaque
BCL2 interacting protein 2
Mouse
Rat
Dog
BCL2 interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:1083]
Pathways (12)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Myogenesis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Myogenesis
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (41)
1 – 10 of 41
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.98
Data Source: Reactome,STRINGDB
SPAG9
Tbio
Family: Enzyme
Novelty: 0.00527315
Score: 0.976
Data Source: Reactome,STRINGDB
CDON
Tbio
Novelty: 0.00447262
Score: 0.937
Data Source: Reactome,STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.923
Data Source: STRINGDB
CDH2
Tbio
Novelty: 0.00040112
Score: 0.917
Data Source: Reactome,STRINGDB
ABL1
Tclin
Family: Kinase
Novelty: 0.00023803
Score: 0.912
Data Source: Reactome,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.91
Data Source: Reactome,STRINGDB
MEF2D
Tbio
Family: TF
Novelty: 0.00732653
Score: 0.906
Data Source: STRINGDB
MEF2A
Tbio
Family: TF
Novelty: 0.00439393
Score: 0.902
Data Source: STRINGDB
MEF2C
Tbio
Family: TF
Novelty: 0.00232724
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.56

PubMed score by year
PubTator Score  35.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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