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Tbio
NPRL3
GATOR complex protein NPRL3

Protein Summary
Description
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. The function of the encoded protein is not known. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611875
  • ENSP00000478273
  • ENSG00000103148
  • ENST00000620134
  • ENSP00000483814

Symbol
  • C16orf35
  • CGTHBA
  • MARE
  • MARE
  • NPR3
  • HS-40
  • RMD11
  • CGTHBA
  • FFEVF3
  • C16orf35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
tissue sample
0.77
cell type or tissue
0.76
disease
0.69
phenotype
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.17   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.17   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
NPRL2
Tbio
Family:  Enzyme
Novelty:  0.02848752
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.999983104
p_ni:  0.000016895
Score:  0.617
Data Source:  BioPlex,Reactome,STRINGDB
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.98450518
p_ni:  0.015494819
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.97845624
p_ni:  0.021543753
p_wrong:  6e-9
Data Source:  BioPlex
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.849026612
p_ni:  0.15078048
p_wrong:  0.000192908
Score:  0.208
Data Source:  BioPlex,STRINGDB
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.804787137
p_ni:  0.195212863
Score:  0.25
Data Source:  BioPlex,STRINGDB
SPRYD7
Tdark
Novelty:  0.25334319
p_int:  0.777521576
p_ni:  0.222344134
p_wrong:  0.00013429
Data Source:  BioPlex
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.775180323
p_ni:  0.22481633
p_wrong:  0.000003347
Data Source:  BioPlex
DEPDC5
Tbio
Novelty:  0.0177511
Score:  0.999
Data Source:  Reactome,STRINGDB
WDR24
Tdark
Novelty:  0.48411996
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
7
14
17
99.9
mean corpuscular volume
3
8
10
98.5
reticulocyte measurement
3
13
18
98.3
mean corpuscular hemoglobin
2
4
4
97.6
red blood cell distribution width
5
6
8
97.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
17
99.9
mean corpuscular volume
10
98.5
reticulocyte measurement
18
98.3
mean corpuscular hemoglobin
4
97.6
red blood cell distribution width
8
97.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NPR3 like, GATOR1 complex subunit
VGNC:9389
453785
Macaque
NPR3 like, GATOR1 complex subunit
722264
Mouse
MGI:109258
17168
Rat
RGD:1308665
360505
Dog
NPR3 like, GATOR1 complex subunit
VGNC:43931
611588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NPR3 like, GATOR1 complex subunit
Macaque
NPR3 like, GATOR1 complex subunit
Mouse
Rat
Dog
NPR3 like, GATOR1 complex subunit
Publication Statistics
PubMed Score 97.17
PubMed score by year
PubTator Score 17.39
PubTator score by year
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Related Publications
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PMID
Year
Title