Tbio ABR Active breakpoint cluster region-related protein

Protein Summary

Description

GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q12979
• B3KW89
• B7Z6H7
• D3DTH3
• D3DTH4
• F5H3S2
• F5H8B3
• Q13693
• Q13694

Gene Name

• ABR

Ensembl ID

• ENST00000291107
• ENSP00000291107
• ENSG00000159842
• ENST00000302538
• ENSP00000303909
• ENST00000543210
• ENSP00000445198
• ENST00000544583
• ENSP00000442048
• ENST00000611009
• ENSP00000484030
• ENSG00000276016
• ENST00000611021
• ENSP00000483168
• ENSG00000278741
• ENST00000612118
• ENSP00000481740
• ENST00000615642
• ENSP00000479455
• ENST00000620619
• ENSP00000478880
• ENST00000625740
• ENSP00000486511
• ENST00000627258
• ENSP00000486214

Symbol

• MDB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
biological process	0.86
interacting protein	0.86
transcription factor	0.86
transcription factor binding site profile	0.7

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Active Breakpoint Cluster Region-related Protein

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Active Breakpoint Cluster Region-related Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.3   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.3   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0