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Tbio
ABR
Active breakpoint cluster region-related protein

Protein Summary
Description
GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291107
  • ENSP00000291107
  • ENSG00000159842
  • ENST00000302538
  • ENSP00000303909
  • ENST00000543210
  • ENSP00000445198
  • ENST00000544583
  • ENSP00000442048
  • ENST00000611009
  • ENSP00000484030
  • ENSG00000276016
  • ENST00000611021
  • ENSP00000483168
  • ENSG00000278741
  • ENST00000612118
  • ENSP00000481740
  • ENST00000615642
  • ENSP00000479455
  • ENST00000620619
  • ENSP00000478880
  • ENST00000625740
  • ENSP00000486511
  • ENST00000627258
  • ENSP00000486214

Symbol
  • MDB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.86
interacting protein
0.86
transcription factor
0.86
transcription factor binding site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.87   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.87   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
5
96.5
basophil count
1
1
0
2.3
45.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
96.5
basophil count
0
2.3
45.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ABR, RhoGEF and GTPase activating protein
VGNC:54163
454407
Macaque
active BCR-related
721180
Mouse
MGI:107771
109934
Rat
RGD:1306279
287537
Dog
ABR, RhoGEF and GTPase activating protein
VGNC:37481
480638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ABR, RhoGEF and GTPase activating protein
Macaque
active BCR-related
Mouse
Rat
Dog
ABR, RhoGEF and GTPase activating protein
Pathways (12)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Protein-Protein Interactions (34)
1 – 10 of 34
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.965
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.942
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.94
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.937
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.932
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.93
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.00412327
Score: 0.929
Data Source: STRINGDB
RHOBTB2
Tbio
Novelty: 0.00734789
Score: 0.926
Data Source: STRINGDB
RHOV
Tbio
Family: Enzyme
Novelty: 0.02138482
Score: 0.925
Data Source: STRINGDB
RHOF
Tbio
Family: Enzyme
Novelty: 0.01795771
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  175.87

PubMed score by year
PubTator Score  54.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer