PTP4A2
Protein tyrosine phosphatase type IVA 2
Protein Summary
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants ...more
- ENST00000457805
- ENSP00000409260
- ENSG00000184007
- ENST00000602683
- ENSP00000473490
- ENST00000602725
- ENSP00000473259
- ENST00000647444
- ENSP00000493688
- ENST00000649841
- ENSP00000497092
- PRL2
- PTPCAAX2
- HH13
- OV-1
- PRL2
- HH7-2
- PRL-2
- PTP4A
- HU-PP-1
- PTPCAAX2
- ptp-IV1a
- ptp-IV1b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.96 | ||
transcription factor binding site profile | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 154.81 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 154.81 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1