Tbio PPP1R8 Nuclear inhibitor of protein phosphatase 1

Protein Summary

Description

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q12972
• Q5TEJ2
• Q5TEJ4
• Q5TIF2
• Q6PKF6
• Q9UBH1
• Q9UBZ0
• NIPP-1

Gene Name

• PPP1R8

Ensembl ID

• ENST00000236412
• ENSP00000236412
• ENSG00000117751
• ENST00000311772
• ENSP00000311677
• ENST00000373931
• ENSP00000363042

Symbol

• ARD1
• NIPP1
• ARD1
• ARD-1
• NIPP1
• NIPP-1
• PRO2047

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
kinase perturbation	0.93
molecular function	0.81
transcription factor perturbation	0.8
hub protein	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 893.42   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 361   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 893.42   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 361   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0