Tbio NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3

Protein Summary

Description

Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Uniprot Accession IDs

• Q12968
• O75211
• Q14516
• Q99840
• Q99841
• Q99842
• NF-ATc3

Gene Name

• NFATC3

Ensembl ID

• ENST00000329524
• ENSP00000331324
• ENSG00000072736
• ENST00000346183
• ENSP00000300659
• ENST00000349223
• ENSP00000264008

Symbol

• NFAT4
• NFAT4
• NFATX
• NF-AT4c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
protein domain	0.85
virus perturbation	0.85
molecular function	0.84
biological process	0.82

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 3

Protein / ... / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 3

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Rel Homology Transcription Factor / Nuclear Factor Of Activated T-cells, Cytoplasmic 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.82   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 279   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.82   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0