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Tbio
NFATC3
Nuclear factor of activated T-cells, cytoplasmic 3

Protein Summary
Description
Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329524
  • ENSP00000331324
  • ENSG00000072736
  • ENST00000346183
  • ENSP00000300659
  • ENST00000349223
  • ENSP00000264008

Symbol
  • NFAT4
  • NFAT4
  • NFATX
  • NF-AT4c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
protein domain
0.85
virus perturbation
0.85
molecular function
0.84
biological process
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.67   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.67   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
4
4
97.8
apolipoprotein A 1 measurement
1
3
3
96.5
blood metabolite measurement
2
2
3
91.8
glomerular filtration rate
3
2
2
6.4
73.4
metabolite measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
97.8
apolipoprotein A 1 measurement
3
96.5
blood metabolite measurement
3
91.8
glomerular filtration rate
2
6.4
73.4
metabolite measurement
1
70.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 3
VGNC:9092
454184
Macaque
nuclear factor of activated T-cells 3
702390
Mouse
MGI:103296
18021
Rat
RGD:1308692
361400
Dog
nuclear factor of activated T cells 3
VGNC:43769
479678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T cells 3
Macaque
nuclear factor of activated T-cells 3
Mouse
Rat
Dog
nuclear factor of activated T cells 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12968-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Calcineurin activates NFAT
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
CLEC7A (Dectin-1) signaling
Calcineurin activates NFAT
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (80)
1 – 10 of 80
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999918369
p_ni:  0.000080327
p_wrong:  0.000001304
Data Source:  BioPlex
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.945358116
p_ni:  0.054641882
p_wrong:  2e-9
Score:  0.303
Data Source:  BioPlex,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.997
Data Source:  STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
Score:  0.987
Data Source:  STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
Score:  0.973
Data Source:  Reactome,STRINGDB
MAPK10
Tchem
Family:  Kinase
Novelty:  0.00420573
Score:  0.963
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.959
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.958
Data Source:  STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
Score:  0.957
Data Source:  STRINGDB
MAP3K1
Tchem
Family:  Kinase
Novelty:  0.0041131
Score:  0.948
Data Source:  STRINGDB
Publication Statistics
PubMed Score  169.67

PubMed score by year
PubTator Score  67.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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