RALGDS
Ral guanine nucleotide dissociation stimulator
Protein Summary
Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
- ENST00000372047
- ENSP00000361117
- ENSG00000160271
- ENST00000372050
- ENSP00000361120
- ENST00000372062
- ENSP00000361132
- ENST00000393157
- ENSP00000376864
- ENST00000393160
- ENSP00000376867
- KIAA1308
- RGF
- RGF
- RGDS
- RalGEF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
transcription factor binding site profile | 0.86 | ||
transcription factor perturbation | 0.74 | ||
transcription factor | 0.72 | ||
tissue sample | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 309.55 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 309.55 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0