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Tbio
RALGDS
Ral guanine nucleotide dissociation stimulator

Protein Summary
Description
Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372047
  • ENSP00000361117
  • ENSG00000160271
  • ENST00000372050
  • ENSP00000361120
  • ENST00000372062
  • ENSP00000361132
  • ENST00000393157
  • ENSP00000376864
  • ENST00000393160
  • ENSP00000376867

Symbol
  • KIAA1308
  • RGF
  • RGF
  • RGDS
  • RalGEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.86
transcription factor perturbation
0.74
transcription factor
0.72
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
4
5
92
low density lipoprotein cholesterol measurement
1
1
1
81.1
total cholesterol measurement
1
1
1
80.4
hematocrit
1
1
1
80.3
eosinophil percentage of leukocytes
2
2
4
76.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
92
low density lipoprotein cholesterol measurement
1
81.1
total cholesterol measurement
1
80.4
hematocrit
1
80.3
eosinophil percentage of leukocytes
4
76.9
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ral guanine nucleotide dissociation stimulator
VGNC:9195
464824
Mouse
MGI:107485
19730
Rat
RGD:3533
29622
Dog
ral guanine nucleotide dissociation stimulator
480686
Horse
ral guanine nucleotide dissociation stimulator
100069402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ral guanine nucleotide dissociation stimulator
Mouse
Rat
Dog
ral guanine nucleotide dissociation stimulator
Horse
ral guanine nucleotide dissociation stimulator
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12967-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by NTRK1 (TRKA)
Reactome
Signaling by NTRKs
Reactome
Signaling by Receptor Tyrosine Kinases
Reactome
Signalling to ERKs
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by NTRK1 (TRKA)
Signaling by NTRKs
Signaling by Receptor Tyrosine Kinases
Signalling to ERKs
Protein-Protein Interactions (94)
1 – 10 of 94
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.998
Data Source:  Reactome,STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.99
Data Source:  Reactome,STRINGDB
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
Score:  0.986
Data Source:  Reactome,STRINGDB
RALB
Tbio
Family:  Enzyme
Novelty:  0.01605746
Score:  0.985
Data Source:  Reactome,STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.979
Data Source:  Reactome,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.974
Data Source:  STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.96
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.958
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.948
Data Source:  STRINGDB
PDPK1
Tchem
Family:  Kinase
Novelty:  0.00430458
Score:  0.945
Data Source:  STRINGDB
Publication Statistics
PubMed Score  255.00

PubMed score by year
PubTator Score  313.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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