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Tbio
TAF10
Transcription initiation factor TFIID subunit 10

Protein Classes
Protein Summary
Description
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299424
  • ENSP00000299424
  • ENSG00000166337

Symbol
  • TAF2A
  • TAF2H
  • TAFII30
  • TAF2A
  • TAF2H
  • TAFII30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
protein complex
0.92
hub protein
0.88
virus perturbation
0.85
molecular function
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.55   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.55   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 10
VGNC:13383
450998
Macaque
TATA-box binding protein associated factor 10
710022
Mouse
MGI:1346320
24075
Mouse
MGI:3648850
216185
Rat
RGD:1305907
293345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor 10
Macaque
TATA-box binding protein associated factor 10
Mouse
Mouse
Rat
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q12962-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
Disease
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
Disease
Gene expression (Transcription)
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (147)
1 – 10 of 147
TAF12
Tbio
Novelty: 0.04352637
p_int: 0.999896081
p_ni: 0.000103778
p_wrong: 1.42e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF8
Tbio
Novelty: 0.01056638
p_int: 0.999706454
p_ni: 0.000293546
Score: 0.999
Data Source: BioPlex,STRINGDB
TAF7L
Tbio
Novelty: 0.08132691
p_int: 0.999622556
p_ni: 0.000377355
p_wrong: 8.9e-8
Score: 0.992
Data Source: BioPlex,STRINGDB
SUPT20H
Tbio
Novelty: 0.00625899
p_int: 0.999399342
p_ni: 0.000600515
p_wrong: 1.44e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
TADA1
Tdark
Novelty: 0.09903801
p_int: 0.997795487
p_ni: 0.002202993
p_wrong: 0.00000152
Score: 0.996
Data Source: BioPlex,STRINGDB
TAF6L
Tdark
Family: Enzyme
Novelty: 0.7411477
p_int: 0.996680465
p_ni: 0.003319244
p_wrong: 2.91e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
TADA2B
Tbio
Family: TF
Novelty: 0.06387677
p_int: 0.995268351
p_ni: 0.004731438
p_wrong: 2.11e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
SPATA25
Tbio
Novelty: 0.80142563
p_int: 0.966736375
p_ni: 0.01740068
p_wrong: 0.015862945
Data Source: BioPlex
ATXN7L3
Tbio
Novelty: 0.1572083
p_int: 0.909512699
p_ni: 0.04692655
p_wrong: 0.043560752
Score: 0.995
Data Source: BioPlex,STRINGDB
TADA3
Tbio
Novelty: 0.01743814
p_int: 0.908613876
p_ni: 0.008254726
p_wrong: 0.083131398
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  31.55

PubMed score by year
PubTator Score  16.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer