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Tbio
ANK3
Ankyrin-3

Protein Summary
Description
In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280772
  • ENSP00000280772
  • ENSG00000151150
  • ENST00000355288
  • ENSP00000347436
  • ENST00000373827
  • ENSP00000362933
  • ENST00000503366
  • ENSP00000425236

Symbol
  • MRT37
  • ANKYRIN-G
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
biological process
0.97
trait
0.97
microRNA
0.95
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.64   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.64   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
COPI-mediated anterograde transport
Reactome
Developmental Biology
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
COPI-mediated anterograde transport
Developmental Biology
ER to Golgi Anterograde Transport
Gene Ontology Terms (56)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (219)
1 – 10 of 219
RAPGEF5
Tbio
Novelty: 0.02176235
p_int: 0.999999985
p_ni: 1.5e-8
Score: 0.218
Data Source: BioPlex,STRINGDB
PALM2
Tbio
Novelty: 0.07313425
p_int: 0.999999789
p_ni: 2.11e-7
Score: 0.226
Data Source: BioPlex,STRINGDB
BTF3
Tbio
Novelty: 0.00931722
p_int: 0.99999898
p_ni: 0.00000102
Data Source: BioPlex
CHL1
Tbio
Novelty: 0.0005177
p_int: 0.99999857
p_ni: 0.00000143
Score: 0.612
Data Source: BioPlex,STRINGDB
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.06135268
p_int: 0.999997804
p_ni: 0.000002196
Data Source: BioPlex
MAPK8IP1
Tbio
Family: Enzyme
Novelty: 0.00125562
p_int: 0.999997159
p_ni: 0.000002841
Score: 0.223
Data Source: BioPlex,STRINGDB
FEZ1
Tbio
Novelty: 0.03725421
p_int: 0.999993726
p_ni: 0.000006274
Score: 0.203
Data Source: BioPlex,STRINGDB
HIF1AN
Tbio
Novelty: 0.01079184
p_int: 0.999944311
p_ni: 0.000055689
Score: 0.239
Data Source: BioPlex,STRINGDB
UXS1
Tbio
Family: Enzyme
Novelty: 0.0861244
p_int: 0.999783239
p_ni: 0.000216761
Score: 0.156
Data Source: BioPlex,STRINGDB
PWP1
Tbio
Novelty: 0.12867675
p_int: 0.99906317
p_ni: 0.00093683
Score: 0.255
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  181.64

PubMed score by year
PubTator Score  125.96

PubTator score by year